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Research interest |
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Regulation of chromatin structure and function |
The eukaryotic chromosome architecture has many levels of compaction, starting with the repeating nucleosomal unit, in which DNA associated with core histone proteins to form chromatin. The structure of chromatin prevents regulatory factors from access to DNA and can potentially effect any biological process such as transcription, replication, recombination, and repair to occur. My research interest focuses on the roles of both the core histones and nonhistone regulatory proteins in regulating chromatin structures in vivo and on the mechanisms by which chromatin remodeling factors relieve its inhibitory role in the biological functions. The major emphasis is on how chromatin remodeling and histone modifications play roles in transcription regulation. |
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Histone modifications and cancer |
Epigenetic mechanisms, involve both DNA methylation and histone modifications. Our interest is encouraged by the fact that many of the pathways that lead to the modification of histones are important determinants of tumorigenesis through their association with abnormal gene expression.
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