Hans Chun-Hung Lin's lab
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List of Publications
98) Chem Asian J., 8(12), 3191-3199 (2013)
B. Ghosh, Y.-H. Lai, Y.-Y. Shih, T. K. Pradhan, C.-H. Lin*, K.-K. T. Mong
Total Synthesis of a Glycoglycerolipid from Meiothermus taiwanensis through a One-Pot Glycosylation Reaction and Exploration of its Immunological Properties
97) Proc. Natl. Acad. Sci. USA, 110(34), 13809-13814 (2013)
S.-F. Liao, C.-H. Liang, M.-Y. Ho, T.-L. Hsu, T.-I. Tsai, Y. S.-Y. Hsieh, S.-T. Li, Y.-Y. Cheng, S.-M. Tsao, T.-Y. Lin, Z.-Y. Lin, W.-B. Yang, C.-T. Ren, K.-I. Lin, C.-H. Lin, H.-Y. Hsu, C.-Y. Wu, C.-H. Wong*
Immunization of fucose-containing polysaccharides from Reishi mushroom induces antibodies to tumor-associated Globo H-series epitopes
96) Proc. Natl. Acad. Sci. USA, 110(27), 10928-10933 (2013)
H.-W. Huang, C.-H. Chen, C.-H. Lin, C.-H. Wong, K.-I. Lin*
B-cell maturation antigen is modified by a single N-glycan chain that modulates ligand binding and surface retention"
95) Chem Soc Rev., 42(10), 4459-4475 (2013)
Z. Tu, Y.-N. Lin, C.-H. Lin*
Development of fucosyltransferase and fucosidase inhibitors
94) Tetrahedron, 69(19), 3991-3999 (2013)
Z.-P. Lin, F.-F. Wong, Y.-B. Chen, C.-H. Lin, M.-T. Hsieh, J.-C. Lien, Y.-H. Chou, H.-C. Lin
Regioselective and Reductive Cleavage of Allyl Ethers by NaBH4-HOAc
93) Chem Asian J., 8(7), 1536-1550 (2013)
Z. Tu, H.-W. Hsieh, C.-M. Tsai, C.-W. Hsu, S.-G. Wang, K.-J. Wu, K.-I. Lin*, C.-H. Lin*
Synthesis and characterization of sulfated Gal-β-1, 3/1,4 -GlcNAc disaccharides through consecutive protection /glycosylation steps
92) Med Chem Comm, 4(5), 783-791 (2013)
J.-T. Wang, T.-C. Lin, Y.-H. Chen, C.-H. Lin* and J.-M. Fang*
Polyhydroxylated pyrrolidine and 2-oxapyrrolizidine as glycosidase inhibitors
91) ChemBioChem, 14(7), 813-817 (2013)
J. C.-Y. Lin, C.-C. Chou, S. Gao, S.-C. Wu, K.-H. Khoo, C.-H. Lin*
An in vivo tagging method reveals That Ras undergoes sustained activation upon transglutaminase-mediated protein serotonylation
90) Chem Commun, 49(39), 4265-4267 (2013)
S.-M. Chang, Z. Tu, H.-M. Jan, J.-F. Pan, C.-H. Lin*
Rapid synthesis of oligomannosides with orthogonally protected monosaccharides
89) Tetrahedron, 69(11), 2494-2500 (2013)
Z.-P. Lin, F.-F. Wong, Y.-B. Chen, Y.-C. Lin, M. Kimura, K. Kaneko, H. Takayama, J.-B. Wu, C.-H. Lin*, H.-C. Lin*,
Synthesis of α-2-Deoxy-Ulosides by Michael Addition of Hex-1-en-3-ones
88) Chem Commun, 48(72), 9083-9085 (2012)
R. A. Davis, C.-H. Lin, J. Gervay-Hague
Chemoenzymatic synthesis of cholesteryl-6-O-tetradecanoyl-α-D-glucopyranoside: A product of host cholesterol efflux promoted by Helicobacter pylori
87) Angew Chem Int Ed Engl., 51(24), 5871-5875 (2012)
Chiang BY, Chou CC, Hsieh FT, Gao S, Lin JC, Lin SH, Chen TC, Khoo KH, Lin CH.
In Vivo Tagging and Characterization of S-Glutathionylated Proteins by a Chemoenzymatic Method
86) Future Virology, 7(6), 621-633 (2012)
Y.-F. Wang, W.-I. Liao, Y.-D. Kuo, S.-Y. Guu, H.-C. Wang, C.-H. Lin, I.-J. Su, C.-F. Chang
Receptor binding surveillance of influenza clinical isolates
85) Adv. Synth. Catal, 354(9), 1750-1758 (2012)
Y.-N. Lin, D. B. Stein, S.-W. Lin, S.-M. Chang, T.-C. Lin, Y.-R. Chuang, J. Gervay-Hague, H. Narimatsu, C.-H. Lin
Chemoenzymatic Synthesis of GDP-l-Fucose Derivatives as Potent and Selective α-1,3-Fucosyltransferase Inhibitors
84) Apoptosis, 17(2), 154-163 (2012)
P.-Y. Yang, W.-X. Chen, F.-Y. Chang, H.-W. Chen, C.-H. Lin, Y.-C. Hsu, J. Hsieh Wu
HepG2 cells infected with Klebsiella pneumonia show DNA laddering at apoptotic and necrotic stages
83) Carbohydrate Research, 346(2), 183-190 (2011)
Shih TL, Liang MT, Wu KD, C.-H. Lin
Synthesis of polyhydroxy 7- and N-alkyl-azepanes as potent glycosidase inhibitors
82) Bioresource Technol, 102(21), 10136-10138 (2011)
C.-M. Chau, K.-J Liu, C.-H. Lin
Enzymatic synthesis of sialic acid derivatives by immobilized lipase from Candida antarctica
81) Chembiochem, 12(15), 2306-2309 (2011)
C.-M. Chong, S. Gao, B.-Y. Chiang, W.-H. Hsu, T.-C. Lin, T.-C. Chen, C.-H. Lin*
An Acyloxymethyl Ketone-Based Probe to Monitor the Activity of Glutathionylspermidine Amidase in Escherichia coli
80) J Immunol, 187(4), 1643-1652 (2011)
C.-M. Tsai, C.-H. Guan, H.-W. Hsieh, T.-L. Hsu, K.-J. Wu, Z.-J. Tu, C.-H. Lin*, K.-I. Lin*
Galectin-1 and galectin-8 have redundant roles in promoting plasma cell formation
79) Tetrahedron, 67 (34), 6362-6368 (2011)
H.-C. Lin, J.-F. Pan, Y.-B. Chen, Z.-P. Lin, C.-H. Lin*
"Stereoselective glycosylation of endo-glycals by microwave- and AlCl3-assisted catalysis
78) J Struct Biol, 175(3), 300-310 (2011)
Y.-Y. Chen, T.-P. Ko, C.-H. Lin, W.-H. Chen, A. H.-J. Wang*
Conformational change upon product binding to Klebsiella pneumoniae UDP-glucose dehydrogenase: A possible inhibition mechanism for the key enzyme in polymyxin resistance
77) Future Med Chem, 3(3), 283-296 (2011)
W.-I. Liao, Y.-F. Wang, Y.-D. Kuo, Y.-D., C.-H. Lin, T.-C. Chang I.-J. Su, J.-R. Wang, C.-F. Chang*
Profiling of influenza viruses by high-throughput carbohydrate membrane array
76) Glycobiology, 21(7), 895-902 (2011)
C.-F. Chang, J.-F. Pan, C.-N. Lin, I.-L. Wu, C.-H. Wong, C.-H. Lin*
Rapid characterization of sugar-binding specificity by in-solution proximity binding with photosensitizers
75) J Biol Chem, 286(16), 14057-14064 (2011)
C.-Y. Chou, T.-P. Ko, K.-J. Wu, K.-F. Huang, C.-H. Lin, C.-H. Wong, A. H.-J. Wang*
Modulation of substrate specificities of D-sialic acid aldolase through single mutation of Val251
74) Protein Sci, 20(3), 557-566 (2011)
P.-H. Pai, H.-J. Wu, C.-H. Lin*, A. H.-J. Wang*
Structure and mechanism of E. coli glutathionylspermidine amidase belonging to the family of cysteine, histidine-dependent amidohydrolase/peptodase
73) Exp Biol Med, 236(2), 219-26 (2011)
P.-C. Pan, H.-W. Chen, P.-K. Wu, Y.-Y. Wu, C.-H. Lin, J.-H. Wu*
Mutation in fucose synthesis gene of Klebsiella pneumonia affects capsule composition and virulence in mice
72) Tetrahedron, 66(27-28), 5229-5234 (2010)
Hui-Chang Lin, Yen-Bo Chen, Zi-Ping Lin, Fung Fuh Wong, Chun-Hung Lin and Shao-Kai Lin
Synthesis of 1,7-dioxaspiro[5.5]undecanes and 1-oxa-7-thiaspiro[5.5]undecanes from exo-glycal
71) ChemBioChem, 11(14), 1971-1974 (2010)
A. L. van Bueren, S. D. Popat, C.-H. Lin, G. J. Davies
Structural and Thermodynamic Analysis of α-L-Fucosidase Inhibitors
70) J. Biol. Chem, 285(33), 25345-25353 (2010)
B.-Y. Chiang, T.-C. Chen, C.-H. Pai, C.-C. Chou, H.-H. Chen, T.-P. Ko, W.-H. Hsu, C.-Y. Chang, W.-F. Wu, A. H.-J. Wang, C.-H. Lin
Protein S-Thiolation by Glutathionylspermidine (Gsp): The role of E. coli Gsp synthetase/amidase in redox regulation
69) ACS Chem. Biol. 5(5), 489-497 (2010)
C.-W. Ho, S. D. Popat, T.-W. Liu, K.-C. Tsai, M.-J. Ho, W.-H. Chen, A.-S. Yang and C.-H. Lin
Development of GlcNAc-Inspired Iminocyclitiols as Potent and Selective N-Acetyl-β-Hexosaminidase Inhibitors
68) Angew. Chem. Int. Ed. 49(2), 337-340 (2010)
H.-J. Wu, C.-W. Ho, T.-P. Ko, S.s. Popat, C.-H Lin and A.H.-J.Wang
Structural Basis of α-Fucosidase Inhibition by Iminocyclitols with Ki Values in the Micro- to Picomolar Range
67) Journal of Structural Biology 169(1), 25-35 (2010)
Y.-Y. Chen, T. P. Ko, W.-H. Chen, L.-P. Lo, C.-H. Lin, A. H.-J. Wang
Conformational changes associated with cofactor/substrate binding of 6-phosphogluconate dehydrogenase from Escherichia coli and Klebsiella pneumoniae: Implications for enzyme mechanism
66) Tetrahedr.Lett. 50, 7327-7329 (2009)
H.-C. Lin, H.-H. Wu, Z.-P. Lin, C.-Y. Lin, C.-H. Lin, K.-L. Chen, F. F. Wong,
Microwave-assisted stereoselective α-2-deoxyglycosylation of hex-1-en-3-uloses
65) Proc. Natl. Acad. Sci. USA 106, 14581-14586 (2009)
T.-W. Liu, C.-W. Ho, H.-H. Huang, S.-M. Chang, S. D. Popat, Y.-T. Wang, M.-S. Wu, Y.-J. Chen and C.-H. Lin
Role for α-L-Fucosidase in the Control of Helicobacter pylori–infected Gastric Cancer Cells
64) Biochemistry, 48, 110-120 (2009)
S.-W. Liu, C.-S. Chen, S.-S. Chang, K.-K. Mong, C.-H. Lin, C.-W. Chang, C.-Y. Tang, Y.-K. Li
Identification of essential residues of human alpha-L-fucosidase and tests of its mechanism
63) J. Biol. Chem. 283, 12343-12353 (2008)
H.-J. Hsu, K.-C. Tsai, Y.-K. Sun, H.-J. Chang, Y.-J. Huang, H.-M. Yu, C.-H. Lin, S.-S. Mao, A.-S. Yang
Factor-XaActive Site Substrate Specificity with Substrate Phage Display and Computational Molecular Modeling
62) Blood 112, 3661-3670 (2008)
C.-S. Shi, G-Y. Shi, S.-M. Hsiao, Y.-C. Kao, K.-L. Kuo, C.-Y. Ma, C.-H. Kuo, B.-I. Chang, C.-F. Chang, C.-H. Lin, C.-H. Wong, H.-L. Wu
Lectin-like domain of thrombomodulin binds to its specific ligand Lewis y antigen and neutralizes lipopolysaccahride-induced inflammatory response.
61) Infection and Immunity 76, 1170-1178, (2008)
C. Y. Yeh, C. N. Lin, C. F. Chang, C. H. Lin, H. T. Lien, J. Y. Chen and J. S. Chia.
C-terminal repeats of Clostridium difficile toxin A induce production of chemokine and adhesion molecules in endothelial cells and promote migration of leukocytes.
60) Adv. Synth. Catal. 350, 2313-2321, (2008)
D. B. Stein, Y.N. Lin, C.H. Lin.
Characterization of Helicobacter pylori α1,2-Fucosyltransferase for Enzymatic Syntehsis of Tumor-Associated Antigens.
59) Bioorg. Med. Chem. 16, 4652-4660, (2008)
Y.M. Shao, W.B. Yang, T.H. Kuo, K.C. Tsai, C.H. Lin, A.S. Yang, P.H. Liang, C.H. Wong
Design, synthesis, and evaluation of trifluoromethyl ketones as inhibitors of SARS-CoV 3CL protease.
58) ChemBioChem 8, 1654-1657 (2007)
Y.-M. Shao, W.-B. Yang, H.-P. Peng, M.-F. Hsu, K.-C. Tsai, T.-H. Kuo, A.H.-J. Wnag, P.-H. Liang, C.-H. Lin, A.-S. Yang, C.-H. Wong
Structure-based design and synthesis of highly potent SARS-CoV 3CL protease inhibitors.
57) J. Org. Chem. 72, 4258-4261, (2007)
T.-L. Shih, R.-Y. Yang, S.-T. Li, S.-H. Wang, C.-F. Chiang, C.-H. Lin
Expeditious Synthesis of Tri- and Tetrahydroxyazepanes from D-(-)-Quinic Acid as Potent Glycosidase Inhibitors.
56) J. Biol. Chem. 282, 9973-9982, (2007)
H.-Y. Sun, T.-P. Ko, S.-W. Lin, J.-L. Liu, A. H.-J. Wang and C.-H. Lin
Structure and Mechanism of Helicobacter pylori Fucosyltransferase: A Basis for LPS Variation and Inhibitor Design
55) EMBO J. 25, 5970-5982, (2006)
C.-H. Pai, B.-Y. Chiang, T.-P. Ko, C.-C Chou, C.-M. Chong, F.-J. Yen, S. Chen, J. K. Coward, A. H.-J. Wang and C.-H. Lin
Dual binding sites for translocation catalysis by Escherichia coli glutathionylspermidine synthetase
54) J. Virol. Methods 137, 82-87, (2006)
Y.-S. E. Cheng, K.-H. Lo, H.-H. Hsu, Yi-Ming Shao, W.-B.Yang, C.-H. Lin, C.-H. Wong
Screening for HIV protease inhibitors by protection against activity-mediated cytotoxicity in E. coli
53) J. Biol. Chem. 281, 38653-38662, (2006)
H.-J. Lee, Y.-S. Chen, C.-Y. Chou, C-H. Chien, C.-H. Lin, G. G. Chang, X. Chen
Investigation of the dimer interface and substrate specificity of prolyl dipeptiase DPP8
52) Biochemistry. 45, 8108-8116, (2006)
S.-W. Lin, T.-M. Yuan, J.-R. Li and C.-H. Lin
Carboxy1 Terminus of Helicobacter pylori α1,3-Fucosyltransferase Determines the Structure and Stability
51) Biochemistry. 45, 7006-7012, (2006)
C.-H. Chien, C.-H. Tsai, , C.-H. Lin, C.-Y. Chou, X. Chen
Identification of hydrophobic residues critical for DPP-IV dimerization
50) Carbohydr. Res. 341, 1428-1437, (2006)
S.-J. Hsu, H.-C. Lin, C.-H. Lin
Inter- and Intramolecular Glycosylation of exo-Glycals Promoted by Metallic Lewis Acid
49) Biochemistry. 45, 5695-5702, (2006)
C.-W. Ho, C.-F. Chang, Y.-N. Lin, H.-T. Lee, Y.-T. Wu, C.-Y. Wu, S.-W. Liu, Y.-K. Li, C.-H. Lin
Discovery of Different Types of Inhibition between the Human and Thermotoga maritime a-Fucosidases by Fuconojirimycin-Based Derivatives
48) Cancer Research. 66, 2937-45, (2006)
J. Yin, A. Hashimoto, M. Izawa, K. Miyazaki, G.-Y. Chen, H. Takematsu, Y. Kozutsumi, A. Suzuki, K. Furuhata, F.-L. Cheng, C.-H. Lin, C. Sato, K. Kitajima and R. Kannagi
Hypoxic culture induces expression of sialin, a sialic acid transporter, and cancer-associated gangliosides containing non-human sialic acid on human cancer cells
47) J. Biol. Chem. 281, 7605-13, (2006)
S.-C. Chen, Y.-C. Chang, C.-H. Lin, C.-H. Lin, and S.-H. Liaw
Crystal Structure of Bifunctional Deaminase and Reductase from Bacillus Substilus Involved in Riboflavin Biosynthsis
46) J. Biomed. Sci. 13, 59-72, (2006)
C.-K. Chang, S.-C. Sue, T.-H. Yu, C.-M. Hsieh, C.-K. Tsai, Y.-C. Chiang, S.-J Lee, H.-H. Hsiao, W.-J. Wu, W.-L. Chang, C.-H. Lin and T.-H. Huang
Modular Organization of SARS Coronavirus Nucleocapsid Protein
45) J. Med. Chem. 48, 4469-4473, (2005)
J.-J. Shie, J.-M. Fang, C.-J. Kuo, T.-H. Kuo, P.-H. Liang, H.-J. Huang, W.-B. Yang, C.-H. Lin, J.-L. Chen, Y.-T. Wu, and C.-H. Wong
Discovery of Potent Anilide Inhibitors against the Severe Acute Respiratory Syndrome 3CL Protease
44) Curr. Topics Med. Chem. 5, 1431-1457, (2005)
C.-H. Lin, H.-C. Lin, W.-B. Yang
exo-Glycals: Some General Aspects and Synthetic Applications for Biochemical Use
43) Tetrahedron Lett. 46, 5071-5076, (2005)
H.-C. Lin, W.-P. Du, C.-C. Chang, C.-H. Lin
Different Reaction Routes Found in Acid-Catalyzed Glycosylation of endo- and exo-Glycals: Competition between Ferrier Rearrangement and Protonation
42) Adv. Synth. Catal 347, 967-972, (2005)
C.-F. Teo, T.-S. Hwang, P.-H. Chen, C.-H. Hung, H.-S. Gao, L.-S. Chang, C.-H. Lin
Synthesis of Sialyl TN Glycopeptides― Enzymatic Sialylation by α2,6-Sialyltransferase from Photobacterium damsela
41) Tetrahedron 61, 1855-1862, (2005)
Fan, G.-T.; Pan, Y.-s.; Lu, K.-C.; Cheng, Y.-P.; Wong, C.-H.; Lin, W.-C.; Lin, C.-H.; Fang, J.-M.; Lin, C.-C.
Synthesis of a-Galactosyl Ceramide and the Related Glycolipids for Evaluation of Their Activities on Mouse Splenocytes
40) Tetrahedron: Asymmetry. 16, 297-301, (2005)
H.-C. Lin, C.-C. Chang, J.-Y. Chen, C.-H. Lin
Streoselective Glycosylation of exo-Glycals by Microwave-assisted Ferrier Rearrangement
39) J. Am. Soc. Mass Spectrom. 16, 324-332, (2005)
H.-H. Huang, H.-K. Liao, Y.-J. Chen, T.-S. Hwang, Yi-Han Lin, C.-H. Lin
Structural Characterization of Sialic Acid Synthase by Electrospray Mass Spectrometry: A Tetrameric Enzyme Composed of Dimeric Dimers
38) J. Immunol. 173, 5989-5999, (2004)
H.-Y. Hsu, K.-F. Hua, C.-C. Lin, C.-H. Lin, J. Hsu, C.-H. Wong
Extract of Reishi Polysaccharides Induces Cytokine Expression via TLR4-Modulated Protein Kinase Signaling pathways
37) Chem. & Biol. 11, 1301-1306, (2004)
C.-F. Chang, C.-W. Ho, C.-Y. Wu, C.-H. Wong, C.-H. Lin
Discovery of Picomolar Slow Tight-Binding Inhibitors of α-Fucosidase
36) Bioorgaic & Medicinal Chemistry. 12, 5595-5601, (2004)
H.-S. Chen, Y.-F. Tsai, S. Lin, K.-H. Khoo, C.-H. Wong, C.-H. Lin
Studies on the Immuno-modulating and anti-tumor activities of Ganoderma lucidum (Reishi) Polysaccharides
35) Glycobiology. 14, 147-155, (2004)
M.-C. Cheng, C.-H. Lin, Heng-Ru Lin, Yu-Ping Yu, S.-H. Wu*
Hydrolysis, Lactonization, and Identification of α2,8-/α-2,9- Alternately Linked Tri-, Tetra, and Polysialic Acids
34) The Proceedings of the International Symposium on Biomolecular Chemistry 2003. Maruzen Co.: Tokyo, p. 96-99 (2003)
Y.-J. Chen, T.-S. Hwang, X.-H. Hwnag, H.-K. Liao, C.-H. Lin
“Sialic Acid Synthase from Escherichia coli - Structural Characterization by Mass Spectrometry”
33) Angew. Chem. Int. Ed. 42, 4661-4664, (2003)
C.-Y. Wu, C.-F. Chang, S.-Y. Chen, C.-H. Wong, C.-H. Lin
Rapid Diversity-Oriented Synthesis in Microtiter Plates for In Situ Screening: Discovery of Potent and Selective α-Fucosidase inhibitors
32) Org. Lett. 5, 1087-1089, (2003)
W.-B. Yang, H.-C. Lin, Y.-F. Gu, C.-Y. Chen, C.-Y. Wu, C.-C., C.-H. Lin
Stereoselective Glycosylation of exo-Glycals Accelerated by Ferrier-type Rearrangement
31) Tetrahedron Letters 43, 6515-6519, (2002)
C.-F. Chang, W.-B. Yang, C.-C. Chang, C.-H. Lin
Inter- and Intramolecular alcohol additions of exo-Glycals
30) J. Org. Chem. 67, 3773-3782, (2002)
W.-B. Yang, Y.-Y. Yang, Y.-F. Gu, S.-H. Wang, C.-C. Chang, C.-H. Lin
Stereochemistry in the Synthesis and Reaction of exo-Glycals
29) Biochem. Biophys. Res. Commun. 295, 167-173, (2002)
T.-S. Hwang, C.-H. Hung, C.-F. Teo, G.-T. Chen, L.-S. Chang, S.-F. Chen, Y.-J. Chen, C.-H. Lin
Structural Characterization of Escherichia coli Sialic Acid Synthase
28) Bioorgaic & Medicinal Chemistry. 10, 1057-1062, (2002)
Y.-Y. Wang, K.-H. Khoo, S.-T. Chen, C.-C. Lin, C.-H. Wong, C.-H. Lin
Studies on the Immuno-modulating and Antitumor Activities of Ganoderma lucidum (Reishi) Polysaccharides: Functional and Proteomic Analysis of a Fucose-containing Glycoprotein Fraction Responsible for the Activities
27) Tetrahedron 58, 253-259, (2002)
W.-B. Yang, Sachindra S. Patil, C.-H. Tsai, C.-H. Lin, J.-M. Fang
The Synthesis of L-Gulose and L-Xylose from D-gluconolactone
26) Tetrahedron Letters 42, 6907-6910, (2001)
W.-B. Yang, T.-I. Wu, C.-C. Chang, S.-H. Wang, C.-F. Teo, C.-H. Lin
Facile Synthesis of Conjugated exo-Glycals
25) Tetrahedron Letters 42, 4567-4660, (2001)
W.-B. Yang, C.-F. Chang, S.-H. Wang, C.-F. Teo, C.-H. Lin
Expeditious Synthesis of C-Glycosyl Conjugated Dienes and Aldehydes from Sugar Lactones
24) Adv Exp Med Biol. 491, 215-230, (2001)
C.-H. Lin, C.-C. Lin
Enzymatic and Chemical Approaches for the Synthesis of Sialyl Glycoconjugates
23) J. Org. Chem. 66, 5248-5251, (2001)
Y.-P. Yu, M.-C. Cheng, H.-R. Lin, Y.-F. Tsai, C.-H. Lin, S.-H. Wu
Acid-Catalyzed Hydrolysis and Lactonization of α2,8-Linked Oligosialic Acid
22) Angew. Chem. Int. Ed. 39, 772-776 (2000)
M.-C. Cheng, C.-H. Lin, H.-Y. Wang, H.-R. Lin, S.-H. Wu
Regioselective Lactonization of Tetrasialic Acid
21) J. Org. Chem. 65, 5565-5574, (2000)
M. D. Burkart, M. Izumi, E. Chapman, C.-H. Lin, C.-H. Wong
Regeneration of PAPS for the Enzymatic Synthesis of Sulfated Oligosaccharides
20) Synlett 2000, 1634-1636, (2000)
Y.-Y. Yang, W.-B. Yang, C.-F. Teo, C.-H. Lin
Regioselective Deprotection of tert-Butyldimethylsilyl Ethers by Boron Trichloride
19) Tetrahedron Letters 41, 2569-2572, (2000)
W.-B. Yang, C.-H. Tsai, C.-H. Lin
The Expeditious Preparation and Reactivity of Some Protected Forms of Gluconolactone
18) Sialobiology and Other Novel Forms of Glycosylation” Edited by Y. Inoue, Y.-C. Lee, F. A. Troy II; Gakushin Publishing Company: Osaka, p. 45-50 (1999)
Lin, C. H.; Cheng, M. C.; Khoo, K. H.; Wu, S. H.
“Regioselective Lactonization of α-2,8-Trisialic Acid”
17) Angew. Chem. Int. Ed. 38, 686-689, (1999)
M.-C. Cheng, C.-H. Lin, K.-K. Khoo, S.-H. Wu
Regioselective Lactonization of α-2,8-Trisialic Acid
16) Chemitstry & Biology 4, 859-866 (1997)
C.-H. Lin, S. Chen, D. S. Kwon, J. K. Coward, C. T. Walsh
Aldehyde and Phosphinate Analogs of Glutathione and Glutathionyl--spermidine: Potent, Selective Binding Inhibitors of the E. coli Bifunctional Glutathionylspermidine Synthetase/Amidase
15) Biochemistry 36, 14930-14938 (1997)
C.-H. Lin, D. S. Kwon, J. M. Borlinger, Jr., C. T. Walsh
Evidence for a Glutathionyl-enzyme Intermediate in the Amidase Activity of the Bifunctional Glutathionylspermidine Synthetase/Amidase from Escherichia coli
14) J. Med. Chem. 40, 3842-3850 (1997)
S. Chen, C.-H. Lin, D. S. Kwon, C. T. Walsh, J. K. Cowar
Design, Synthesis, and Biochemical Evaluation of Phosphonate and Phosphonamidate Analogs of Glutathionylspermidine as Inhibitors of Glutathionylspermidine Synthetase/Amidase from Escherichia coli
13) Proc. Natl. Acad. Sci. USA 94, 10040-10044 (1997)
I.-S. Park, C.-H. Lin, C. T. Walsh
Bacterial Resistance to Vancomycin: Overproduction, Purification, and Characterizationof VanC2 from Enterococcus casseliflavus as a D-Alanyl-D-Serine Ligase
12) Bioorg. Med. Chem. Lett. 7, 505-510 (1997)
S. Chen, C.-H. Lin, C. T. Walsh, J.K. Coward
Novel Inhibitors of Trypanothione Biosynthesis: Synthesis and Evaluation of a Phosphinate Analog of Glutathionyl Spermidine (GSP), A Potent, Slow-Binding Inhibitor of GSP Synthetase
11) J. Biol. Chem. 272, 2429-2436 (1997)
D. S. Kwon, C.-H. Lin, S. Chen, J. K. Coward, C. T. Walsh, J. M. Borlinger, Jr.
Dissection of of Glutathionyl Spermidine Synthetase/Amidase from E. coli into Autonomously Folding and Functional Synthetase and Amidase Domains
10) Tetrahedron Letters 38, 2649-2652 (1997)
C.-C. Lin, C.-H. Lin, C.-H. Wong
Sialic Acid Aldolase-Catalyzed Condensation of Pyruvate and N-Substituted Mannosamine: A Useful Method for the Synthesis of N-Substituted Sialic Acids
9) Biochemistry 36, 780-785 (1997)
C.-H. Lin, W. M. Brion, I. R. Ollmann, C.-H. Wong
Why is CMP-Ketodeoxyoctonate Highly Unstable?
8) Biochemistry 35, 10464-10471 (1996)
I.-S. Park, C.-H. Lin, C. T. Walsh
Gain of D-Alanyl-D-Lactate or D-Lactyl-D-Alanine Synthetase Activities in Three Active Site Mutants of the E. coli D-Alanyl-D-Alanine LigaseB
7) J. Am. Chem. Soc. 117, 8031-8032 (1995)
C.-H. Lin, G.-J. Shen, E. Garcia-Junceda, C.-H. Wong
Enzymatic Synthesis and Regeneration of 3'-Phosphoadenosine-5'-Phosphosulfate (PAPS) for Regioselective Sulfation of Oligosaccharides
6) Ph.D. Thesis, August (1995)
C.-H. Lin
“Enzymes in Carbohydrate Synthesis”
5) Bioorg. Med. Chem. 3, 1625-1630 (1995)
C.-H. Lin, M. Shimazaki, C.-H. Wong, M. Koketsu, L. R. Juneja, M. Kim
Enzymatic Synthesis of Sialyl Lewis x Dimer from Egg Yolk
4) J. Chem. Soc. Perkin Trans 1, 967-978, (1995)
J.-M. Fang, C.-H. Lin, C. W. Bradshaw, C.-H. Wong
Enzyme in Organic Synthesis: Oxidoreductions
3) Bioorg. Med. Chem. 3, 313-320, (1995)
T. Sugai, C.-H. Lin, G.-J. Shen, C.-H. Wong
CMP-KDO Synthetase: Overproduction and Application to the Synthesis of CMP-KDO and Analogs
2) Pure. & Apply. Chem. 65, 803-808 (1993)
C.-H. Wong, Y. Ichikawa, T. Kajimoto, K. K.-C. Liu, G.-J. Shen, C.-H. Lin, Y.-F. Wong, D. P. Dumas, Y.-C. Lin, R. Wang, G. Look
Practical Synthesis of Carbohydrates Based on Aldolases and Glycosyl Transferases
1) J. Am. Chem. Soc. 114, 10138-10145 (1992)
C.-H. Lin, T. Sugai, R. L. Halcomb, Y. Ichikawa, C.-H. Wong
Unusual Stereoselectivity in Sialic Acid Aldolase-Catalyzed Aldol Condensations: Synthesis of Both Enantiomers of High Carbon Monosaccharides


1) C.-H. Wong, C.-H. Lin, US Patent Application Serial No. 07/946,546 (1992)
"Ketoaldonic Acids Having Formed Stereogenic Centers of R-Configuration: Methods and Compositions"
US patent No. 6,353,095, issued in Mar 2002.
2) C.-H. Wong, C.-H. Lin, G.-J. Shen. US Patent Application Serial No. 08/408,774, Mar 1995
"One-pot Enzymatic Sulfation Process Using 3'-Phosphoadenosine-5'-phosphosulfate and Recycled Phosphorylated Adenosine Intermediates "
US patent No. 5,919,673, issued in Jul 1999.
3) Y.-Y. Wang, K.-H. Khoo, S.-T. Chen, C.-C. Lin, C.-H. Wong, C.-H. Lin
US Provisional Patent (Sep. 2001)
“Studies on the Immuno-modulating and Antitumor Activities of Ganoderma lucidum (Reishi) Polysaccharides: Functional and Proteomic Analysis of a Fucose-containing Glycoprotein Responsible for the Activities”
4) W.-B. Yang, H.-C. Lin, C.-H. Lin
“Stereoselective Glycosylation of exo-Glycals Accelerated by Ferrier-type Rearrangement” Submitted for Patent application
5) C.-F. Chang, C.-H Lin
US Provisional Patent
“Rapid Characterization of Sugar-Binding Specificity and Glycan Profiles by In-Solution Proximity Binding with Photosensitizers”
6) C.-W. Ho and C.-H. Lin
US Provisional Patent
“Discovery of Potent and Selective Hexosaminidase Inhibitors for Therapeutic Development”
7) T.-W. Liu and C.-H. Lin
US Patent (Application No. 12/806,084 filed on August 2, 2010)
“Role of humanα-L-fucosidase 2 in the diagnosis and therapeutic target for Helicobacter pylori-associated gastric diseases”


1) 中研院周報1001期
2) 健康靈芝2005春季號

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