1.    Lee CH, Saw JE, Chen EH, Wang CH, Uchihashi T, (Chen RP)* (2024-04) accepted "The positively charged cluster in the N-terminal disordered region may affect prion protein misfolding: Cryo-EM structure of hamster PrP(23-144) fibrils." Journal of Molecular Biology

2.    Chen EH, Wang CH, Liao YT, Chan FY, Kanaoka Y, Uchihashi T, Kato K, Lai L, Chang YW, Ho MC*, (Chen RP)* (2023-09) "Visualizing the membrane disruption action of antimicrobial peptides by cryo-electron tomography." Nature Communications 14, 5464

3.    Wang DT, Tang TYC, Kuo CT, Yu YT, Chen EHL, Lee MT, Tsai RF, Chen HY, Chiang YW*, (Chen RPY)* (2023-05) "Cholesterol twists the transmembrane Di-Gly region of amyloid-precursor protein." PNAS nexus 2(5), pgad162

4.    Chu BK, Lin YS, Shen HC, (Chen RP)* (2023) "Cross-Seeding Assay in the Investigation of the Amyloid Core of Prion Fibrils." Methods in Molecular Biology 2551, 633-647

5.    Chen EH, Kao HW, Lee CH, Huang JYC, Wu KP*, (Chen RP)* (2022-08) "2.2 Å Cryo-EM Tetra-Protofilament Structure of the Hamster Prion 108-144 Fibril Reveals an Ordered Water Channel in the Center." Journal of the American Chemical Society 144(30), 13888-13894

6.    Chen EH, Lin KM, Sang JC, Ho MR, Lee CH, Shih O, Su CJ, Yeh YQ, Jeng US, (Chen RP)* (2022-08) "Condition-dependent structural collapse in the intrinsically disordered N-terminal domain of prion protein." IUBMB life 74(8), 780-793

7.    Lo WL, Wang YH, Chen EH, Wang SM, Chen LC, (Chen RP)* (2022-07) "Biodistribution analysis of an intranasal-delivered peptide by the nanoSPECT/CT imaging. Journal of Drug Delivery Science and Technology 73, 103454

8.    Chu BKY, Tsai RF, Hung CL, Kuo YH, Chen EH., Chiang YW*, Chan SI*, (Chen RP)* (2022-06) "Location of the cross-β structure in prion fibrils: A search by seeding and electron spin resonance spectroscopy." Protein Science 31(6), e4326

9.    Chen EH, Weng CW, Li YM, Wu MC, Yang CC, Lee KT, (Chen RP)*, Cheng CP* (2021-09) "De Novo Design of Antimicrobial Peptides With a Special Charge Pattern and Their Application in Combating Plant Pathogens." Frontiers in Plant Science 12, 753217

10.    Matiadis D, Ng ST, Chen EH, Nigianni G, Vidali VP, Canko A, (Chen RP)*, Sagnou M* (2021-08) "Synthesis and Biological Evaluation of Hydroxylated Monocarbonyl Curcumin Derivatives as Potential Inducers of Neprilysin Activity." Biomedicines 9(8), 955

11.    Chen SP, Chen EH, Yang SY, Kuo PS, Jan HM, Yang TC, Hsieh MY, Lee KT, Lin CH , (Chen RP) (2021-06) "A Systematic Study of the Stability, Safety, and Efficacy of the de novo Designed Antimicrobial Peptide PepD2 and Its Modified Derivatives Against Acinetobacter baumannii." Frontiers in Microbiology 12, 678330

12.    Lin YC, Chen EH, (Chen RP), Dunny GM, Hu WS, Lee KT (2021-06) "Probiotic Bacillus Affect Enterococcus faecalis Antibiotic Resistance Transfer by Interfering with Pheromone Signaling Cascades." Applied and environmental microbiology 87(13), e0044221

13.    Sneideris T, Ziaunys M, Chu BY, (Chen RP), Smirnovas V (2020-10) "Self-Replication of Prion Protein Fragment 89-230 Amyloid Fibrils Accelerated by Prion Protein Fragment 107-143 Aggregates." Int. J. Mol. Sci. 21(19), E7410

14.    Shen HC, Chen YH, Lin YS, Chu BK, Liang CS, Yang CC, (Chen RP) (2019-06) "Segments in the Amyloid Core that Distinguish Hamster from Mouse Prion Fibrils." Neurochemical research 44(6), 1399-1409

15.    Chen ZT, Hung MJ, Yu SJ, Liao TY, Lin YP, (Chen RP), Yang CC, Charng YY (2019-02) "Divergence in Thermostability of Arabidopsis Mitochondrial Nucleotide Exchange Factors Encoded by Duplicate Genes, MGE1 and MGE2." bioRxiv

16.    Chen EH, Lu TT, Hsu JC, Tseng YJ, Lim TS, (Chen RP) (2017-08) "Directly monitor protein rearrangement on a nanosecond-to-millisecond time-scale." Scientific reports 7(1), 8691

17.    Cheng YS, Chen ZT, Liao TY, Lin C, Shen HC, Wang YH, Chang CW, Liu RS, (Chen RP), Tu PH (2017-05) "An intranasally delivered peptide drug ameliorates cognitive decline in Alzheimer transgenic mice." EMBO molecular medicine 9(5), 703-715

18.    Wang BJ, Her GM, Hu MK, Chen YW, Tung YT, Wu PY, Hsu WM, Lee H, Jin LW, Hwang SL, (Chen RP), Huang CJ, Liao YF (2017-04) "Erbb2 regulates autophagic flux to modulate the proteostasis of app-ctfs in alzheimer's disease." Proc. Natl. Acad. Sci. U S A 114(15), E3129-E3138

19.    (Chen RP) (2017-03) "From nose to brain: The promise of peptide therapy for alzheimer’s disease and other neurodegenerative diseases." J. Alzheimers Dis. Parkinsonism 7(2), 314

20.    How SC, Yang SM, Hsin A, Tseng CP, Hsueh SS, Lin MS, (Chen RP), Chou WL, Wang SS (2016-12) "Examining the inhibitory potency of food additive fast green FCF against amyloid fibrillogenesis under acidic conditions." Food & function 7(12), 4898-4907

21.    Saito M, Kamonprasertsuk S, Suzuki S, Nanatani K, Oikawa H, Kushiro K, Takai M, Chen PT, Chen EH, (Chen RP), Takahashi S (2016-09) "Significant Heterogeneity and Slow Dynamics of the Unfolded Ubiquitin Detected by the Line Confocal Method of Single-Molecule Fluorescence Spectroscopy." J Phys Chem B. 120(34), 8818-8829

22.    Wu BK, Yuan RY, Chang YP, Lien HW, Chen TS, Chien HC, Tong TS, Tsai HP, Fang CL, Liao YF, Chang CC, (Chen RP), Huang CJ (2016-08) "Epicatechin isolated from Tripterygium wilfordii extract reduces tau-GFP-induced neurotoxicity in zebrafish embryo through the activation of Nrf2." Biochemical and biophysical research communications 477(2), 283-289

23.    Chen PT, Chen ZT, Hou WC, Yu LC, (Chen RP) (2016-07) "Polyhydroxycurcuminoids but not curcumin upregulate neprilysin and can be applied to the prevention of Alzheimer's disease." Scientific Reports 6, 29760

24.    Lin CY, Cheng YS, Liao TY, Lin C, Chen ZT, Twu WI, Chang CW, Tan DT, Liu RS, Tu PH, (Chen RP) (2016-06) "Intranasal Administration of a Polyethylenimine-Conjugated Scavenger Peptide Reduces Amyloid-beta Accumulation in a Mouse Model of Alzheimer's Disease." Journal of Alzheimer's disease 53(3), 1053-1067

25.    Chen PT, Chen CL, Lin LT, Lo CH, Hu CJ, (Chen RP), Wang SS (2016-04) "Design of peptide substrate for sensitively and specifically detecting two Aβ-degrading enzymes: neprilysin and angiotensin-converting enzyme." PLoS One 11(4), e0153360

26.    Hsieh, Y.-L., Lu, C.-F., Chiang, B.-Y., Liao, S.-C., (Chen, R. P.-Y)., Lin, C.-S., Wang, A.-Y. & Yang, C.-C. (2016-04) "Molecular characterization of ethylene response sensor 1 (BoERS1) in Bambusa oldhamii." Plant Mol. Biol. Rep. 34(2), 387-398

27.    Wu BK, Yuan RY, Lien HW, Hung CC, Hwang PP, (Chen RP), Chang CC, Liao YF, Huang CJ (2016-02) "Multiple signaling factors and drugs alleviate neuronal death induced by expression of human and zebrafish tau proteins in vivo." J Biomed Sci 23(1), 25

28.    Yang C, Lo WL, Kuo YH, Sang JC, Lee CY, Chiang YW, (Chen RP) (2015-02) "Revealing Structural Changes of Prion Protein during Conversion from α-Helical Monomer to β-Oligomers by Means of ESR and Nanochannel Encapsulation." ACS chemical biology 10(2), 493-501

29.    Chen Lin, Eric H.-L. Chen, Lily Y.-L. Lee, Ruei-Lin Hsu, Frederick Y. Luh, Li-ling Yang, Chia-Fu Chou, Li-De Huang, Chun-Cheng Lin, (Rita P.-Y. Chen) (2014-03) "Comparison of the anti-amyloidogenic effect of O-mannosylation, O-galactosylation, and O-GalNAc glycosylation." Carbohydrate Research, 387, 46-53

30.    Chuang CC, Liao TY, Chen EH, (Chen RP) (2013-10) "How do amino acid substitutions affect the amyloidogenic properties and seeding efficiency of prion peptides." Amino Acids, 45(4), 785-796

31.    Chatterjee B, Lee CY, Lin C, Chen EH, Huang CL, Yang CC, (Chen RP). (2013-07) "Amyloid core formed of full-length recombinant mouse prion protein involves sequence 127-143 but not sequence 107-126." PLoS One, 8(7), e67967

32.    Hsu JC, Chen HL, Snoeberger RC, Luh FY, Lim TS, Hsu C, (Chen RP) (2013-04) "Thioflavin T and Its Photo-Irradiative Derivatives: Exploring Their Spectroscopic Properties in the Absence and Presence of Amyloid Fibrils. " Journal of physical chemistry B, 117(13), 3459-68

33.    Liu KN, Lai CM, Lee YT, Wang SN, (Chen RP), Jan JS, Liu HS, Wang SS (2012-11) "Curcumin's pre-incubation temperature affects its inhibitory potency toward amyloid fibrillation and fibril-induced cytotoxicity of lysozyme." BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1820(11), 1774-1786

34.    Sang JC, Lee CY, Luh FY, Huang YW, Chiang YW, (Chen RP) (2012-11) "Slow spontaneous alpha-to-beta structural conversion in a non-denaturing neutral condition reveals the intrinsically disordered property of the disulfide-reduced recombinant mouse prion protein." Prion, 6(5), 489-497

35.    Kao AL, Lin YH, (Chen RP), Huang YY, Chen CC, Yang CC (2012-06) "E3-independent ubiquitination of AtMAPR/MSBP1." Phytochemistry, 78, 7-19

36.    Yang, L. L., Kao, M. W., Chen, H. L., Lim, T. S., Fann, W. & (Chen, R. P.)* (2012-02) "Observation of protein folding/unfolding dynamics of ubiquitin trapped in agarose gel by single-molecule FRET." EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 41(2), 189-98

37.    Liao TY, Lee LY, (Chen RP) (2011-11) "Leu-138 in the bovine prion peptide fibrils is involved in the seeding discrimination related to codon-129 M/V polymorphism in the prion peptide seeding experiment." FEBS journal, 278(22), 4351-4361

38.    Chen PT, Liao TY, Hu CJ, Wu ST, Wang SS, (Chen RP) (2010-06) "A highly sensitive peptide substrate for detecting two Abeta-degrading enzymes: Neprilysin and insulin-degrading enzyme." Journal of neuroscience methods, 190(1), 57-62

39.    Huang, T.Y., Cook, C.E., Davis, G. K., Shigenobu, S., (Chen, R.P.) and Chang, C.C.* (2010-02) "Anterior development in the parthenogenetic and viviparous form of the pea aphid, Acyrthosiphon pisum: hunchback and orthodenticle expression." INSECT MOLECULAR BIOLOGY, 19(2), 75-85

40.    Chen, A.K., Lin, R.Y., Xie, E.Z., Tu, P.H., (Chen, R.P.) and Liao, T.Y., Chen, W., Wang, C.H. and Huang, J.H.* (2010-01) "Induction of amyloid fibrils by the C-terminal fragments of TDP-43 in amyotrophic lateral sclerosis." JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 132(4), 1186-1187

41.    Tsai WB*, (Chen RP), Wei KL, Tan SF, Lai JY (2010) "Modulation of RGD-functionalized polyelectrolyte multilayer membrane for promoting osteoblast function." JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION 21(3), 377-94

42.    Chen HL, Hsu JC, Viet MH, Li MS, Hu CK, Liu CH, Luh FY, Chen SS, Chang ES, Wang AH, Hsu MF, Fann W, (Chen RP) (2010-11) "Studying submicrosecond protein folding kinetics using a photolabile caging strategy and time-resolved photoacoustic calorimetry." Proteins, 78(14), 2973-83

43.    Chang ES, Liao TY, Lim TS, Fann W, (Chen RP)* (2009-01) "A new amyloid-like beta-aggregate with amyloid characteristics, except fibril morphology." Journal of molecular biology, 385(4), 1257-65

44.    Hsu RL, Lee KT, Wang JH, Lee LY, (Chen RP)* (2009-01) "Amyloid-degrading ability of nattokinase from Bacillus subtilis natto." Journal of agricultural and food chemistry, 57(2), 503-8

45.    Chang, C.C.*, Huang, T.Y., Cook, C.E., Lin, G.W., Shih, C.L., and (Chen, R.P.) (2009-01) "Developmental expression of Apnanos during oogenesis and embryogenesis in the parthenogenetic pea aphid Acyrthosiphon pisum." Int. J. Dev. Biol., 53(1), 169-176

46.    Lee MM, Isaza CE, White JD, (Chen RP), Liang GF, He HT, Chan SI, Chan MK (2009-11) "Insight into the substrate length restriction of M32 carboxypeptidases: Characterization of two distinct subfamilies." Proteins, 77(3), 647-657

47.    Tsai WB*, (Chen RP), Wei KL, Chen YR, Liao TY, Liu HL, Lai JY (2009-11) "Polyelectrolyte multilayer films functionalized with peptides for promoting osteoblast functions." Acta biomaterialia, 5(9), 3467-3477

48.    Ho CC, Lee LY, Huang KT, Lin CC, Ku MY, Yang CC, Chan SI, Hsu RL, (Chen RP)* (2009-07) "Tuning the conformational properties of the prion peptide." Proteins, 76(1), 213-25

49.    Isaza, C.E., Zhong, X., Rosas, L.E., White, J.D., (Chen, R.P.), Liang, G.F., Chan, S.I., Satoskar, A.R., and Chan, M.K.* (2008-08) "A proposed role for Leishmania major carboxypeptidase in peptide catabolism." Biochem. Biophys. Res. Commun, 373(1), 25-29

50.    (Chen, R.P.), Liang, F.C., Lee, C.T., Zerella, R., and Chan, S.I.* (2008-08) "Contributions of a surface hydrophobic cluster to the folding and structural stability of ubiquitin." J. Chin. Chem. Soc., 55(4), 772-781

51.    Kao, M.W., Yang, L.L., Lin, J.C., Lim, T.S., Fann, W.*, and (Chen, R.P.)* (2008-06) "Strategy for efficient site-specific FRET-dye labeling of ubiquitin." Bioconjug. Chem, 19(6), 1124-1126

52.    Lee, L.Y., and (Chen, R.P.)* (2007-02) "Quantifying the Sequence-Dependent Species Barrier between Hamster and Mouse Prions." J. Am. Chem. Soc., 129, 1644-1652

53.    Liang, F.C., (Chen, R.P.), Lin, C.C., Huang, K.T., and Chan, S.I.* (2006-04) "Tuning the conformation properties of a peptide by glycosylation and phosphorylation." Biochem. Biophys. Res. Commun., 342, 482-488

54.    N. N. Huo, J. J. Huang, J. Miksovska, R. P.Chen, R. W. Larsen and S. I. Chan (2005-12) "Effects of turn stability on the kinetics of refolding of a hairpin in a beta-sheet." J. Am. Chem. Soc., 127, 16945-16954

55.    (Chen, R.P.), Huang, J.J., Chen, H.L., Jan, H., Velusamy, M., Lee, C.T., Fann, W.S., Larsen, R.W., and Chan, S.I.* (2004-05) "Measuring the refolding of beta-sheets with different turn sequences on a nanosecond time scale." Proc. Natl. Acad. Sci. U S A, 101, 7305-7310

56.    R. P. Chen (2004) "The history and new progress of prion diseases." J Gen Mol Biol, 15, 88-95

57.    (Chen, P.Y.), Lin, C.C., Chang, Y.T., Lin, S.C., and Chan, S.I.* (2002-10) "One O-linked sugar can affect the coil-to-beta structural transition of the prion peptide." Proc Natl Acad Sci U S A. 99, 12633-12638

58.    P. Y. Chen, C. K. Lin, C. T. Lee, H. Jan and S. I. Chan (2001) "Effects of turn residues in directing the formation of the beta-sheet and in the stability of the beta-sheet." Protein Sci 10, 1794-1800

59.    P. Y. Chen, B. G. Gopalacushina, C. C. Yang, S. I. Chan and P. A. Evans (2001) "The role of a beta-bulge in the folding of the beta-hairpin structure in ubiquitin." Protein Sci 10, 2063-2074

60.    R. Zerella, P. Y. Chen, P. A. Evans, A. Raine and D. H. Williams (2000) "Structural characterization of a mutant peptide derived from ubiquitin: implications for protein folding." Protein Sci, 9, 2142-2150