Dr. Wen-Shan Li, Institute of Chemistry
Academia Sinica
Laboratory of Medicinal and Bioorganic Chemistry

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  • 2017 年獲台灣藥學會藥物化學研討會最佳論文壁報獎第二名: 2017 年台灣藥學會藥物化學研討會, Wei-Chia Chen (陳維家), Yogy Simanjuntak, Yi-Ling Lin (林宜玲)*, Wen-Shan Li ( 李文山)*, Discovery, Design, and Optimization of New Aromatic-Nitrogen Conjugates against Dengue Virus Infection, June 26-28, 2017, Xitou nature education area, Taiwan.

  • 2017 年獲台灣藥學會藥物化學研討會最佳論文壁報獎佳作: 2017 年台灣藥學會藥物化學研討會, Ching-Ying Shih, Tzu-Ting Chang, Chia-Ling, Chen, Wen-Shan Li*, Glycosylation of Isomalynamide A Analogs Triggers the Anti-migratory Activity and Antiangiogenesis Effect, June 26-28, 2017, Xitou nature education area, Taiwan.

  • 2016年獲第十屆世界華人藥物化學國際研討會最佳論文壁報獎 International Symposium for Chinese Medicinal Chemists (10th ISCMC) The Best Poster Award: Wei-Chia Chen (陳維家), Chih-Wei Fu(傅志偉), Chia-Ling Chen(陳佳鈴), Wen-Shan Li(李文山), SYNTHESIS AND ANTICANCER ACTIVITY EVALUATION OF OXADIAZOLOPYRAZINE DERIVATIVES.

  • 2016年獲第十屆世界華人藥物化學國際研討會最佳論文壁報獎 International Symposium for Chinese Medicinal Chemists (10th ISCMC) The Best Poster Award: Han-En Tsai(蔡函恩), Chih-Wei Fu(傅志偉), Tzu-Ting Chang(張梓庭), Chia-Ling Chen(陳佳鈴) and Wen-Shan Li(李文山), INVESTIGATE THE ROLE OF SIALYLTRANSFERASE INHIBITOR ON MDA-MB-231 BREAST CANCER CELLS IN VITRO AND IN VIVO.

  • Asian Core Program Lectureship Award (to Thailand), 2011, Hong Kong.

  • Annual Best Article Award of J. Chin. Chem. Soc. 2006, 中國化學會

  • 2009年獲第3屆 International Symposium on Bio-Inspired Engineering (ISBIE)壁報佳作: Hui-Chuan Chang, Tzu-Ting Chang, Shu-Chuan Jao, Cheng Heng Wu,Wen-Shan Li*, Chemical rescue of proton relay system in an inactive mutant of human cytosolic aminopeptidase P.

  • 2009年獲第24屆生物醫學聯合學術年會優秀看板論文壁報獎競賽"優良看板論文壁報獎”: Chi-Hsiang Chiang, Chie-Hong Wang, Hui-Chiu Chang, Shivaji V. More, Wen-Shan Li*, Wen-Chun Hung*, 2010, A novel sialyltransferase inhibitor AL10 suppresses invasion and metastasis of lung cancer cells by inhibiting integrin-mediated signaling, Journal of Cellular Physiology 223, 492-499.

Selective Publications

  • Densil Simon, Chien-Huei Chang, Chia-Ling Chen, Alagarsamy Mathavan, Arumugam Ramdass, Veerasamy Sathish, Pounraj Thanasekaran,* Wen-Shan Li,* Seenivasan Rajagopal* 2018, Aggregation Induced Emission Enhancement (AIEE) of Anthracene based Compounds and their Applications as Sensor for BSA and Optical Cell Imaging, Luminescence, accepted, 2018 Feb 10.

  • Andre Wendindonde Nana1, Yu-Tang Chin, Chi-Yu Lin, Yih Ho, Ya-Jung Shih, Yi-Ru Chen, Chun A. Changou, Jens Z. Pedersen, Sandra Incerpi, Leroy F. Liu, Jacqueline Whang-Peng, Earl Fu, Wen-Shan Li, Shaker A Mousa, Hung-Yun Lin*, Paul J. Davis 2018, Tetraiodothyroacetic acid (tetrac) potentiates resveratrol-induced anti-proliferation in colorectal cancers: roles of β-catenin and HMGA2, Endocr. Relat. Cancer, 25(3), 279-293. doi: 10.1530/ERC-17-0450.

  • Hui-Chuan Chang, Camy C.-H. Kung, Tzu-Ting Chang, Shu-Chuan Jao, Yu-Ting Hsu, Wen-Shan Li* 2018, Investigation of the Proton Relay System Operative in Human Cystosolic Aminopeptidase P, PLoS ONE, 13(1):, e0190816.

  • Irulappan Manikandan, Chien-Huei Chang, Chia-Ling Chen, Veerasamy Sathish, Wen-Shan Li*, Mahalingam Malathi* 2017, Aggregation induced emission enhancement (AIEE) characteristics of quinoline based compound — A versatile fluorescent probe for pH, Fe(III) ion, BSA binding and optical cell imaging, Spectrochim. Acta A Mol. Biomol. Spectrosc., 182, 58-66.

  • Tzu-Ting Chang, Gene-Hsiang LeeChi-Che Hsieh, Yi-Ming Shyr, Wen-Ying Liao, Tien-Hua Chen, Shin-E Wang, Peir-Chuen Lu, Pei-Yu Lin, Yan-Bo Chen, Wan-Yu Mao, Hsin-Ying Han, Michael Hsiao, Wen-Bin Yang, Wen-Shan Li, Yuh-Pyng Sher, Chia-Ning Shen* 2017, Elevation of β-galactoside α2,6-sialyltransferase 1 in a fructoseresponsive manner promotes pancreatic cancer metastasis, Oncotarget., 8, 7691-7709.

  • Chia-Chueng Chen, Bor-Cherng Hong,* Wen-Shan Li,* Tzu-Ting Chang, Gene-Hsiang Lee 2017, Synthesis Of Biologically Active Bis(Indolyl)Methane Derivatives by Bisindole Alkylation of Tetrahydroisoquinolines with Visible-Light Induced Ring-Opening Fragmentation, Asian J. Org. Chem., 6, 426-431.

  • Hajjaj H.M. Abdu-Allah, Shih-Ting Huang, Tzu Ting Chang, Chia-Ling Chen, Han-Chung Wu*, Wen-Shan Li* 2016, Nature-inspired design of tetraindoles: Optimization of the core structure and evaluation of structure-activity relationship, Bioorg. Med. Chem. Lett., 26, 4497?4503.

  • Hajjaj H. M. Abdu-Allah, Tzu Ting Chang, Wen-Shan Li* 2016, Synthesis of B- and C-Ring-Modified Lithocholic Acid Analogues as Potential Sialyltransferase Inhibitors, Steroids., 112, 54-61.

  • Chih-Wei Fu, Kai-Hsuan Chang, Ya Ching Jen, Tzu Ting Chang, Wen-Shan Li* 2016, Synthesis of Amino Acid-comprising Sialyltransferase Inhibitors and Their Antimetastatic Activities against Human Breast Cancer Cells, J. Chin. Chem. Soc., 63, 171-180.

  • Chih-Wei Fu, Yun-Jung Hsieh, Tzu Ting Chang, Chia-Ling Chen, Cheng-Yu Yang, Anne Liao, Pei-Wen Hsiao, Wen-Shan Li, 2015, Anticancer efficacy of unique pyridine-based tetraindoles, Eur. J. Med. Chem., 104, 165-176.

  • Mohammad Hassam and Wen-Shan Li, 2015, Copper-catalyzed Markovnikov hydration of alkynes, Tetrahedron, 71, 2719–2723.

  • Chie-Hong Wang, Chia-Ling Chen, Shivaji V. More, Pei-Wen Hsiao, Wen-Chun Hung and Wen-Shan Li, 2014,The tetraindole SK228 reverses the epithelial-to-mesenchymal transition of breast cancer cells by up-regulating members of the miR-200 family, PLoS ONE, 9(6):e101088.

  • Mei-Lin Su, Tsung-Ming Chang, Chi-Hsiang Chiang, Han-Chen Chang, Ming-Feng Hou, Wen-Shan Li, Wen-Chun Hung, 2014, Inhibition of chemokine (C-C Motif) receptor 7 sialylation suppresses CCL19-stimulated proliferation, invasion and anti-anoikis, PLoS ONE, 9(6): e98823.

  • Mohammad Hassam, Shivaji V. More and Wen-Shan Li, 2014, Synthesis of nitrogen-containing benzoannulated eight- and nine-membered heterocycles from methyl 4-amino-3-iodobenzoate, Mendeleev Commun., 24, 159-160.

  • Ramaiyan Sekar, Suresh Kumar Kailasa, Wen-Shan Li, Han-Chung Wu and Hui-Fen Wu, 2013,Rapid separation of acetophenone and its monohydroxy isomers by capillary electrophoresis, Chinese Chem. Lett., 24833-836.

  • Veerasamy Sathish, Eththilu Babu, Arumugam Ramdass, Zong-Zhan Lu, Tzu-Ting Chang, Murugesan Velayudham, Pounraj Thanasekaran, Kuang-Lieh Lu, Wen-Shan Li and Seenivasan Rajagopal, 2013,Photoswitchable alkoxy-bridged binuclear rhenium(I) complexes - a potential probe for biomolecules and optical cell imaging, RSC Adv., 318557-18566.

  • Shivaji V. More, Tzu Ting Chang, Yu-Pin Chiao, Shu-Chuan Jao, Chung-Kuang Lu, and Wen-Shan Li, 2013, Glycosylation Enhances the Anti-migratory Activities of Isomalyngamide A Analogs, Eur. J. Med. Chem., 64169-178.

  • Jia-Yang Chen, Yen-An Tang, Jiunn-Min Shieh, Yu-Ching Chiou, Wen-Shan Li, Yi-Ching Wang, 2013, A synthetic podophyllotoxin derivative exerts anti-cancer effects by inducing mitotic arrest and pro-apoptotic ER stress in lung cancer preclinical models, PLoS ONE, 8(4):e62082.

  • Sin-Ming Huang, Pei-Chun Hsu, Mei-Yu Chen, Wen-Shan Li, Shivaji V. More, Kwok-Tung Lu, Yi-Ching Wang, 2012, The novel indole compound SK228 induces apoptosis and FAK/Paxillin disruption in tumor cell lines and inhibits growth of tumor graft in the nude mouse, Int. J. Cancer, 131, 722-732.

  • Wen-Shan Li, Chie-Hong Wang, Shengkai Ko, Tzu Ting Chang, Ya Ching Jen, Ching-Fa Yao, Shivaji V. More and Shu-Chuan Jao, 2012, Synthesis and Evaluation of the Cytotoxicities of Tetraindoles: Observation that the 5-Hydroxy Tetraindole (SK228) Induces G2 Arrest and Apoptosis in Human Breast Cancer Cells, J. Med. Chem., 55, 1583-1592.

  • Chie-Hong Wang , Ho T. Wu , Hau Man Cheng , Tien-Jui Yen , I-Hsuan Lu , Hui Chuan Chang , Shu-Chuan Jao , Tony Kung Ming Shing , and Wen-Shan Li, 2011, Inhibition of Glutathione S-Transferase M1 by New Gabosine Analogues Is Essential for Overcoming Cisplatin Resistance in Lung Cancer Cells, J. Med. Chem., 54, 8574-8581.

  • Tzu Ting Chang, Shivaji V. More, Norman Lu, Jyun-Wei Jhuo, Yi-Chuan Chen, Shu-Chuan Jao, and Wen-Shan Li, 2011, Polyfluorinated bipyridine cisplatins manipulate cytotoxicity through the induction of S-G2/M arrest and partial intercalation mechanism, Bioorg. Med. Chem., 19, 4887-4894.

  • Chie-Hong Wang, Wei-Chih Shih, Hui Chuan Chang, Yi-Yun Kuo, Wen-Chun Hung,Tiow Gan Ong, and Wen-Shan Li, 2011, Preparation and characterization of amino-linked heterocyclic carbene palladium, gold, and silver complexes and their use as anticancer agents that act by triggering apoptotic cell death, J. Med. Chem., 54, 5245-5249.

  • Tzu Ting Chang, Shivaji V. More, I-Hsuan Lu, Jui-Ching Hsu, Ting-Ju Chen, Ya Ching Jen, Chung-Kuang Lu, and Wen-Shan Li, 2011, Isomalyngamide A, A-1 and their analogs suppress cancer cell migration in vitro, Eur. J. Med. Chem., 46, 3810-3819.

  • Jia-Yang Chen, Yen-An Tang, Sin-Ming Huang, Hsueh-Fen Juan, Li-Wha Wu, Ying-Chieh Sun, Szu-Chi Wang, Kuan-Wei Wu, Gopula Balraj, Tzu-Ting Chang, Wen-Shan Li, Hung-Chi Cheng, and Yi-Ching Wang, 2011, A novel sialyltransferase inhibitor suppresses FAK/paxillin signaling and cancer angiogenesis and metastasis pathways, Cancer Res., 71, 473-483.

  • Chi-Hsiang Chiang, Chie-Hong Wang, Hui-Chiu Chang, Shivaji V. More, Wen-Shan Li, Wen-Chun Hung, 2010, A novel sialyltransferase inhibitor AL10 suppresses invasion and metastasis of lung cancer cells by inhibiting integrin-mediated signaling, Journal of Cellular Physiology, 223, 492-499.

  • Wen-Shan Li, Wing See Lam, Kung-Cheng Liu, Chie-Hong Wang, Hui Chuan Chang,Ya Ching Jen,Yu-Ting Hsu, Sachin Shivatare, Shu-Chuan Jao, 2010, Overcoming the Drug Resistance in Breast Cancer Cells by Rational Design of Efficient Glutathione S-Transferase Inhibitors, Organic Lett., 12, 20-23.

  • Wen-Shan Li, Shivaji V. More, Chie-Hong Wang, Ya Ching Jen, Ching-Fa Yao, Tein-Fu Wang, Chin-Chun Hung, Shu-Chuan Jao, 2010, Synthesis and Structure-activity Relationships of Novel Furazan-3,4-diamide Analogs as Potent Anti-cancer Agents, Bioorganic & Medicinal Chemistry Letters, 20, 1148-1152.

  • Wen-Shan Li, Yi-Ching Wang, Hsueh-Fen Juan (Academia Sinica, Taiwan), 2008, Preparation of l ithocholic acid analogs that inhibit sialyltransferase, U.S. Pat. Appl. Publ., 35pp. CODEN: USXXCO US 2008119443 A1 20080522

  • Yu-Ting Hsu, Chiao-Yung Su, Huang-Chi Du, Shu-Chuan Jao, and Wen-Shan Li, 2008, Evaluation of Organophosphorus Chemicals-Degrading Enzymes: A Comparison of Escherichia coli and Human Cytosolic Aminopeptidase P, Chemistry and Biodiversity, 5, 1401-1411.

  • Ke-Qing Ling, Wen-Shan Li, and Lawrence M, Sayre, 2008, Oxidations of N-(3-Indoleethyl) Cyclic Aliphatic Amines by Horseradish Peroxidase: The Indole Ring Binds to the Enzyme and Mediates Electron-Transfer Amine Oxidation, J. Am. Chem. Soc., 130, 933-944.

  • Wei-Jen Lo, Yu-Ching Chiou, Yu-Ting Hsu, Wing See Lam, Ming-Yun Chang, Shu-Chuan Jao, and Wen-Shan Li, 2007, Enzymatic and Nonenzymatic Synthesis of Glutathione Conjugates: Application to the Understanding of Parasite’s Defense System and Alternative to the Discovery of Potent Glutathione S-Transferase Inhibitors, Bioconjugate Chemistry, 18, 109-120.

  • Kai-Hsuan Chang, Lenselot Lee, Jessica Chen and Wen-Shan Li, 2006, Lithocholic Acid Analogues, New and Potent a-2,3-Sialyltransferase Inhibitors, Chem Comm., 629-631. (This communication is highlighted in the supplement Chemical Biology of Royal Society of Chemistry, 2006, 3 Sialyl transferase inhibition could help treat cancer.)

  • Lenselot Lee, Kai-Hsuan Chang, Famil Valiyev, Hsing-Jang Liuc, Wen-Shan Li, 2006, Synthesis and Biological Evaluation of 5’-Triazole Nucleosides, J. Chin. Chem. Soc., 53, 1547-1556. (JCCS 2007 Annual Best Article Award)

  • Lenselot Lee, Kai-Hsuan Chang, Famil Valiyev, Hsing-Jang Liuc, Wen-Shan Li, 2006, Synthesis and Biological Evaluation of 5’-Triazole Nucleosides, J. Chin. Chem. Soc., 130, 933-944.

  • Shu-Chuan Jao, Li-Fang Huang, Shu-Mei Hwang, and Wen-Shan Li, 2006, Tyrosine 387 and Arginine 404 Are Critical in the Hydrolytic Mechanism of Escherichia coli Aminopeptidase P, Biochemistry, 45, 1547-1553.

  • Li-Fang Huang, Benson Su, Shu-Chuan Jao, Kwang-Ting Liu, and Wen-Shan Li, 2006, Aminopeptidase P-mediated Detoxification of Organophosphonate Analogues of Sarin: Mechanistic and Stereochemical Study at Phosphorus Atom of Substrate, ChemBioChem, 7, 506-514.

  • Shu-Chuan Jao, Jessica Chen, Kelvin Yang, and Wen-Shan Li, 2006, Design of Potent Inhibitors for Schistosoma Japonica Glutathione S-Transferase, Bioorg. Med. Chem., 14, 304-318.

  • Huang-Chi Du, Kung-Cheng Liu, and Wen-Shan Li, 2006, Catalytic Hydrogenation of Halo-Steroidal Derivatives by Bipyridine or Phenanthroline Complexes of Copper(II) in Hydrazine Aqueous Media, Synth. Commun., 36, 621-630.

  • Kai-Hsuan Chang, Ying Shin Tao and Wen-Shan Li, 2004, Synthesis of Anomeric Sulfur Analogues of CMP-Neu5Ac Containing Tethered Alkane or Arene, Synlett. , 1, 37-40.

  • Shu-Chuan Jao, Li-Fang Huang, Ying Shin Tao, and Wen-Shan Li, 2004, Hydrolysis of Organophosphate Triesters by Escherichia coli Aminopeptidase P, J. Mol. Cat. B: Enzym. , 27, 7-12.

  • Wen-Shan Li, Lokman Torun and Harry Morrison, 2003, Intramolecular Sensitization within Steroids. Excited State Interaction of C17 Alpha and Beta Carbon-bromine Bonds with a C6 Carbonyl Group, Can. J. Chem. , 81, 1-9.

  • Craig M. Hill, Wen-Shan Li, James B. Thoden, Hazel M. Holden and Frank M. Raushel, 2003, Enhanced Degradation of Chemical Warfare Agents through Molecular Engineering of Enzyme Active Sites, J. Am. Chem. Soc. , 125, 8990-8991.

  • Kai-Hsuan Chang, Malikah N. Jenkins, Hsin-Ru Wu and Wen-Shan Li, 2003, A Selective Cu(II)/Fe(III)-mediated Hydrogenation of Steroidal Haloalkenes in the Presence of Hydrazine, Tetrahedron Lett., 44, 1351-1354.

  • Wen-Shan Li, Yingchun Li, Craig M. Hill, Karin Lum and Frank M. Raushel, 2002, Enzymatic Synthesis of Chiral Organophosphothioates from Prochiral Precursors, J. Am. Chem. Soc., 124, 3498-3499.

  • Craig M. Hill, Wen-Shan Li, Tu-Chen Cheng, Joseph J. DeFrank and Frank M. Raushel, 2001, Stereochemical Specificity of Organophosphorus Acid Anhydrolase Toward p-Nitrophenyl Analogs of Soman and Sarin, Bioorganic Chemistry, 29, 27-35.

  • Wen-Shan Li, Nanjing Zhang and Lawrence M. Sayre, 2001, N1, N10-Ethylene-Bridged High-Potential Flavins: Synthesis, Characterization, and Reactivity, Tetrahedron, 57, 4507-4522.

  • Wen-Shan Li and Lawrence M. Sayre, 2001, Reaction of Amines with N1, N10-Ethylene-Bridged Flavinium Salts: The First NMR Spectroscopic Evidence of C10a Tetrahedral Amine Adducts, Tetrahedron, 57, 4523-4536.

  • Wen-Shan Li, Karin T. Lum, Misty Chen-Goodspeed, Miguel A. Sogorb and Frank M. Raushel, 2001, Stereoselective Detoxification of Chiral Sarin and Soman Analogs by Phosphotriesterase, Bioorg. Med. Chem. , 9, 2083-2091.

  • Wen-Shan Li and Harry Morrison, 2000, Long-Range Through-Bond Photoactivated s Bond Cleavage in Steroids. Intramolecular Sensitized Debromination, Organic Lett. , 2, 15-18.

  • Wenhong Zhu, Wen-Shan Li, Frank M. Raushel and Gyula Vigh, 2000, Experimental Verification of a Predicted, Previously Unseen Separation Selectivity Pattern in the Capillary Electrophoretic Separation of Noncharged Enantiomers by Octakis(2, 3-diacetyl-6-sulfato)-g-Cyclodextrin, Electrophoresis , 21, 3249-3256.

  • Feiyue Wu, Wen-Shan Li, Misty Chen-Goodspeed, Miguel A. Sogorb and Frank M. Raushel, 2000, Rationally Engineered Mutants of Phosphotriesterase for Preparative Scale Isolation of Chiral Organophosphates, J. Am. Chem. Soc. , 122, 10206-10207.