Dr. Wen-Shan Li, Institute of Chemistry
Academia Sinica
Laboratory of Medicinal and Bioorganic Chemistry

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* 2020誠徵碩士級研究助理一名: 具抗體-藥物接合物 (Antibody-drug conjugate)專長。
* One research assistant (MS) position is available immediately for Antibody-Drug Conjugate studies (available till 2020 Dec).

* 誠徵碩士級研究助理一名: 具細胞生物學研究或動物實驗能力或具蛋白質化學專長。
* One research assistant (MS) position is available immediately for cellular biology (or animal study) or protein chemistry studies.

*2020 誠徵博士後研究人員: 藥物合成或脂質體藥物輸送生物科技相關領域。
* Postdoctoral positions are available for liposome drug delivery (organic chemist) or cancer related projects (cell biologist) (available till 2020 Dec).

Recent Selective publications:

Wei-Chia Chen, Yogy Simanjuntak*, Li-Wei Chu, Yueh-Hsin Ping, Yi-Ling Lee, Yi-Ling Lin* and Wen-Shan Li*, 2020, Benzenesulfonamide Derivatives as Calcium/Calmodulin-Dependent Protein Kinase Inhibitors and Antiviral Agents against Dengue and Zika Virus Infections, J. Med. Chem., 63,1313-1327.

Ching-Ying Shih, Tzu-Ting Chang, Chia-Ling Chen, Wen-Shan Li*, 2020, Antiangiogenic Effect of Isomalyngamide A Riboside CY01 in Breast Cancer Cells via Inhibition of Migration, Tube Formation and pVEGFR2/pAKT Signals, Anticancer Agents Med. Chem., 20,386-399.

Jiao-Ren Huang, Mei-Hsien Lee, Wen-Shan Li and Han-Chun Wu*, 2019, Liposomal Irinotecan for Treatment of Colorectal Cancer in a Preclinical Model, Cancers., 11(3),281.

Andre Wendindonde Nana, Szu Yuan Wu, Yu-Chen SH Yang, Yu-Tang Chin, Tsai-Mu Cheng, Yih Ho, Wen-Shan Li, Yu-Min Liao, Yi-Ru Chen, Ya-Jung Shih, Yun-Ru Liu, Jens Pedersen, Sandra Incerpi, Aleck Hercbergs, Leroy F. Liu, Jacqueline Whang-Peng, Paul J. Davis, Hung-Yun Lin*, 2018, Nano-Diamino-Tetrac (NDAT) Enhances Resveratrol-Induced Antiproliferation by Action on the RRM2 Pathway in Colorectal Cancers, Horm. Cancer., 9(5),349-360.

Shih-Ting Huang, Yi, Ping Wang, Yen-Hui Chen, Chin-Tarng Lin, Wen-Shan Li*, Han-Chung Wu*, 2018, Liposomal Paclitaxel Induces Fewer Hematopoietic and Cardiovascular Complications than Bioequivalent Doses of Taxol, Int. J. Oncol., 53(3),1105-1117.

Densil Simon, Chien-Huei Chang, Chia-Ling Chen, Alagarsamy Mathavan, Arumugam Ramdass, Veerasamy Sathish, Pounraj Thanasekaran,* Wen-Shan Li,* Seenivasan Rajagopal*, 2018, Aggregation Induced Emission Enhancement (AIEE) of Anthracene based Compounds and their Applications as Sensor for BSA and Optical Cell Imaging, Luminescence, 33,780-789.

Andre Wendindonde Nana1, Yu-Tang Chin, Chi-Yu Lin, Yih Ho, Ya-Jung Shih, Yi-Ru Chen, Chun A. Changou, Jens Z. Pedersen, Sandra Incerpi, Leroy F. Liu, Jacqueline Whang-Peng, Earl Fu, Wen-Shan Li, Shaker A Mousa, Hung-Yun Lin*, Paul J. Davis, 2018, Tetraiodothyroacetic acid (tetrac) potentiates resveratrol-induced anti-proliferation in colorectal cancers: roles of β-catenin and HMGA2, Endocr. Relat. Cancer, 25(3),279-293. doi: 10.1530/ERC-17-0450.

Hui-Chuan Chang, Camy C.-H. Kung, Tzu-Ting Chang, Shu-Chuan Jao, Yu-Ting Hsu, Wen-Shan Li*, 2018, Investigation of the Proton Relay System Operative in Human Cystosolic Aminopeptidase P, PLoS ONE, 13(1):e0190816.

Chi-Che Hsieh, Yi-Ming Shyr, Wen-Ying Liao, Tien-Hua Chen, Shin-E Wang, Peir-Chuen Lu, Pei-Yu Lin, Michael Hsiao, Wen-Shan Li, Yuh-Pyng Sher, Chia-Ning Shen*, 2017, Elevation of β-galactoside α2,6-sialyltransferase 1 in a fructoseresponsive manner promotes pancreatic cancer metastasis, Oncotarget, 8,7691-7709.

Irulappan Manikandan, Chien-Huei Chang, Chia-Ling Chen, Veerasamy Sathish, Wen-Shan Li*, Mahalingam Malathi*, 2017, Aggregation induced emission enhancement (AIEE) characteristics of quinoline based compound - A versatile fluorescent probe for pH, Fe(III) ion, BSA binding and optical cell imaging, Spectrochim. Acta A Mol. Biomol. Spectrosc., 182,58-66.

Chia-Chueng Chen, Bor-Cherng Hong*, Wen-Shan Li*, Tzu-Ting Chang, Gene-Hsiang Lee, 2017, Synthesis Of Biologically Active Bis(Indolyl)Methane Derivatives by Bisindole Alkylation of Tetrahydroisoquinolines with Visible-Light Induced Ring-Opening Fragmentation, Asian J. Org. Chem., 26,4497-4503.

Hajjaj H.M. Abdu-Allah, Shih-Ting Huang, Tzu Ting Chang, Chia-Ling Chen, Han-Chung Wu*, Wen-Shan Li*, 2016, Nature-inspired design of tetraindoles: Optimization of the core structure and evaluation of structure–activity relationship, Bioorg Med Chem Lett., 6,426-431.

Hajjaj H. M. Abdu-Allah, Tzu Ting Chang, Wen-Shan Li*, 2016, Synthesis of B- and C-Ring-Modified Lithocholic Acid Analogues as Potential Sialyltransferase Inhibitors, Steroids, 112,54-61.

Chih-Wei Fu, Yun-Jung Hsieh, Tzu Ting Chang, Chia-Ling Chen, Cheng-Yu Yang, Anne Liao, Pei-Wen Hsiao, Wen-Shan Li*, 2015, Anticancer efficacy of unique pyridine-based tetraindoles, Eur. J. Med. Chem., 104,165-176.

Chie-Hong Wang, Chia-Ling Chen, Shivaji V. More, Pei-Wen Hsiao, Wen-Chun Hung and Wen-Shan Li, 2014,The tetraindole SK228 reverses the epithelial-to-mesenchymal transition of breast cancer cells by up-regulating members of the miR-200 family, PLoS ONE, 9(6):e101088.

Mei-Lin Su, Tsung-Ming Chang, Chi-Hsiang Chiang, Han-Chen Chang, Ming-Feng Hou, Wen-Shan Li, Wen-Chun Hung, 2014, Inhibition of chemokine (C-C Motif) receptor 7 sialylation suppresses CCL19-stimulated proliferation, invasion and anti-anoikis, PLoS ONE, 9(6): e98823.

Mohammad Hassam, Shivaji V. More and Wen-Shan Li, 2014, Synthesis of nitrogen-containing benzoannulated eight- and nine-membered heterocycles from methyl 4-amino-3-iodobenzoate, Mendeleev Commun., 24, 159-160.

Ramaiyan Sekar, Suresh Kumar Kailasa, Wen-Shan Li, Han-Chung Wu and Hui-Fen Wu, 2013,Rapid separation of acetophenone and its monohydroxy isomers by capillary electrophoresis, Chinese Chem. Lett., 24833-836.

Veerasamy Sathish, Eththilu Babu, Arumugam Ramdass, Zong-Zhan Lu, Tzu-Ting Chang, Murugesan Velayudham, Pounraj Thanasekaran, Kuang-Lieh Lu, Wen-Shan Li and Seenivasan Rajagopal, 2013, Photoswitchable alkoxy-bridged binuclear rhenium(I) complexes - a potential probe for biomolecules and optical cell imaging, RSC Adv., 318557-18566.

Shivaji V. More, Tzu Ting Chang, Yu-Pin Chiao, Shu-Chuan Jao, Chung-Kuang Lu, and Wen-Shan Li, 2013, Glycosylation Enhances the Anti-migratory Activities of Isomalyngamide A Analogs, Eur. J. Med. Chem., 64169-178.

Jia-Yang Chen, Yen-An Tang, Jiunn-Min Shieh, Yu-Ching Chiou, Wen-Shan Li, Yi-Ching Wang, 2013, A synthetic podophyllotoxin derivative exerts anti-cancer effects by inducing mitotic arrest and pro-apoptotic ER stress in lung cancer preclinical models, PLoS ONE, 8(4):e62082.

Sin-Ming Huang, Pei-Chun Hsu, Mei-Yu Chen, Wen-Shan Li, Shivaji V. More, Kwok-Tung Lu, Yi-Ching Wang, 2012, The novel indole compound SK228 induces apoptosis and FAK/Paxillin disruption in tumor cell lines and inhibits growth of tumor graft in the nude mouse, Int. J. Cancer, 131, 722-732.

Wen-Shan Li, Chie-Hong Wang, Shengkai Ko, Tzu Ting Chang, Ya Ching Jen, Ching-Fa Yao, Shivaji V. More and Shu-Chuan Jao 2012, Synthesis and Evaluation of the Cytotoxicities of Tetraindoles: Observation that the 5-Hydroxy Tetraindole (SK228) Induces G2 Arrest and Apoptosis in Human Breast Cancer Cells, J. Med. Chem., 55, 1583-1592.

Chie-Hong Wang , Ho T. Wu , Hau Man Cheng , Tien-Jui Yen , I-Hsuan Lu , Hui Chuan Chang , Shu-Chuan Jao , Tony Kung Ming Shing , and Wen-Shan Li, 2011, Inhibition of Glutathione S-Transferase M1 by New Gabosine Analogues Is Essential for Overcoming Cisplatin Resistance in Lung Cancer Cells, J. Med. Chem., 54, 8574-8581.

Tzu Ting Chang, Shivaji V. More, Norman Lu, Jyun-Wei Jhuo, Yi-Chuan Chen, Shu-Chuan Jao, and Wen-Shan Li, 2011, Polyfluorinated bipyridine cisplatins manipulate cytotoxicity through the induction of S-G2/M arrest and partial intercalation mechanism, Bioorg. Med. Chem., 19, 4887-4894.

Chie-Hong Wang, Wei-Chih Shih, Hui Chuan Chang, Yi-Yun Kuo, Wen-Chun Hung,Tiow Gan Ong, and Wen-Shan Li, 2011, Preparation and characterization of amino-linked heterocyclic carbene palladium, gold, and silver complexes and their use as anticancer agents that act by triggering apoptotic cell death, J. Med. Chem., 54, 5245-5249.

Tzu Ting Chang, Shivaji V. More, I-Hsuan Lu, Jui-Ching Hsu, Ting-Ju Chen, Ya Ching Jen, Chung-Kuang Lu, and Wen-Shan Li, 2011, Isomalyngamide A, A-1 and their analogs suppress cancer cell migration in vitro, Eur. J. Med. Chem., 46, 3810-3819.

Jia-Yang Chen, Yen-An Tang, Sin-Ming Huang, Hsueh-Fen Juan, Li-Wha Wu, Ying-Chieh Sun, Szu-Chi Wang, Kuan-Wei Wu, Gopula Balraj, Tzu-Ting Chang, Wen-Shan Li, Hung-Chi Cheng, and Yi-Ching Wang, 2011, A novel sialyltransferase inhibitor suppresses FAK/paxillin signaling and cancer angiogenesis and metastasis pathways, Cancer Res., 71, 473-483.

Research Highlights:  

Design of potent inhibitors for glutathione S-transferases. A new type noncompetitive a-2,3-sialyltransferase inhibitor.
Go To Reference.

Proton relay system in aminopeptidase P.

Migration assay 1 Migration assay 2

18O experiment for determination of AMPP detoxification mechanism.

JCCS Annual Best Article Award: