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Drug Discovery in Antimetastatic and Antiproliferative Agents: |
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Expanding access to lead identification
through natural product screening and organic synthesis allows the discovery
of invaluable new chemical entities against cancers. The strategies also involve Antibody-Drug Conjugates and Liposome Drug Delivery System.
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Enzyme Kinetics and Mechanism:: |
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Elucidation of catalytic mechanism for proton relay system and its biological role in vitro and in vivo.
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Enzymatic Bioremediation:: |
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Discovery of new functions of proteins to detoxify the environmental contaminants (insecticides) and exploration of detoxification pathways.
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Cellular (Animal) Studies: : |
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Identification of cellular target protein, pathway and drug metabolites in vitro (via strategy of bionanotechnology) and in vivo.
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Artificial enzyme:: |
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Establishing the catalytic power of artificial catalyst, mimic of the active site complex of metalloenzyme.
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研究領域： |
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新抗轉移及抗癌藥物的研發:
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由天然物篩選和有機合成方法找尋新的先導藥物以利新化學物質發展來對抗癌症。這些策略還涉及抗體-藥物結合物和脂質體藥物遞送系統。 |
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酵素動力學和反應機構:
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研究氫離子傳達系統的催化機制及其在體外或體內所扮演的生物功能角色。 |
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酵素生物復育:
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開發蛋白質的新功能來達成有效分解自然界中人造污染物(殺蟲劑)並分析酵素解毒功能的反應途徑。 |
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細胞(動物)研究:
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利用細胞及動物模式研究藥物之分子機轉、目標蛋白/路徑鑑定及分析藥物代謝產物(藉由生物奈米科技技術)。 |
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人工酵素:
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建構似金屬酵素反應中心且具化學催化能力之(巨)分子化合物。 |
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