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Publications from BCF Users

AUC (ProteomeLab XL-I, Beckman)

Athira Saju, Po-Pang Chen, Tzu-Han Weng, Su-Yi Tsai, Akihiro Tanaka, Yu-Ting Tseng, Chih-Chia Chang, Chun-Hsiung Wang, Yuta Shimamoto and Kuo-Chiang Hsia, 2024, HURP binding to the vinca domain of β-tubulin accounts for cancer drug resistance, Nature Communications, 15: 8844. https://doi.org/10.1038/s41467-024-53139-y * also listed in publications using GatorPlus.

Petra Štěrbová, Chun-Hsiung Wang, Kathleen J. D. Carillo, Yuan-Chao Lou, Takayuki Kato, Keiichi Namba, Der-Lii M. Tzou and Wei-Hau Chang, 2024, Molecular mechanism of pH-induced protrusion configuration switching in piscine betanodavirus implies a novel antiviral strategy, ACS Infect. Dis., 10, 3304-3319. https://pubs.acs.org/doi/10.1021/acsinfecdis.4c00407

Min-Feng Hsu, Manoj Kumar Sriramoju, Chih-Hsuan Lai, Yun-Ru Chen, Jing-Siou Huang, Tzu-Ping Ko, Kai-Fa Huang, and Shang-Te Danny Hsu, 2024, Structure, dynamics, and stability of the smallest and most complex 7₁ protein knot, J. Biol. Chem., 300(1), 105553. https://doi.org/10.1016/j.jbc.2023.105553

Lou, Yuan-Chao, Tu, Cheng-Fen, Chou, Chun-Chi, Yeh, Hsin-Hong, Chien, Chia-Yu, Sadotra, Sushant, Chen, Chinpan, Yang, Ruey-Bing, and Hsu, Chun-Hua, 2024, Structural insights into the role of N-terminal integrity in PhoSL for core-fucosylated N-glycan recognition, Int J Biol Macromol 255, 128309. * also listed in publications using iTC200.

I-Fan Tu, Tzu-Lung Lin, Feng-Ling Yang, I. Ming Lee, Wei-Lin Tu, Jiahn-Haur Liao, Tzu-Ping Ko, Wen-Jin Wu, Jia-Tsrong Jan, Meng-Ru Ho, Ching-Yi Chou, Andrew H. J. Wang, Chung-Yi Wu, Jin-Town Wang, Kai-Fa Huang, and Shih-Hsiung Wu,2022, Structural and Biological Insights into Klebsiella Pneumoniae Surface Polysaccharide Degradation by a Bacteriophage K1 Lyase: Implications for Clinical Use, Journal of Biomedical Science 29, 9. DOI:110.1186/s12929-022-00792-4

Kumar Jangam Vikram, Tien-Sheng Tseng, Yuan-Chao Lou, Shu-Yi Wei, Tsung-Han Wu, Hao-Cheng Tang, Yi-Chih Chiu, Chun-Hua Hsu, and Chinpan Chen ,2022, Structural insights into DNA binding domain of vancomycin-resistance-associated response regulator in complex with its promoter DNA from Staphylococcus aureus, Protein Sci 31, e4286. DOI:10.1002/pro.4286 * also listed in publications using CD.

Wei-Ming Wang, Chen-Hsu Yu, Jing-Yuan Chang, Ting-Hsuan Chen, Yan-Chen Chen, Yi-Ting Sun, Szu-Huan Wang, Shu-Chuan Jao and Richard P. Cheng, 2021, Insertion of Pro-Hyp-Gly provides 2 kcal mol−1 stability but attenuates the specific assembly of ABC heterotrimeric collagen triple helices, Org. Biomol. Chem., 19, 1860-1866. DOI: 10.1039/D0OB02190C

Eric H.-L. Chen, Kuei-Ming Lin, Jason C. Sang, Meng-Ru Ho,Chih-Hsuan Lee, Orion Shih, Chun-Jen Su, Yi-Qi Yeh, U-Ser Jeng and Rita P.-Y. Chen, 2021, Condition-dependent structural collapse in the intrinsically disordered N-terminal domain of prion protein, IUBMB Life, published on web. https://doi.org/10.1002/iub.2528

Manuel Maestre-Reyna, Wei-Cheng Huang, Wen-Jin Wu, Praveen K. Singh, Raimo Hartmann, Po-Hsun Wang, Cheng-Chung Lee, Takaaki Hikima, Masaki Yamamoto, Yoshitaka Bessho, Knut Drescher, Ming-Daw Tsai and Andrew H.-J. Wang, 2021, Vibrio cholerae biofilm scaffolding protein RbmA shows an intrinsic, phosphate-dependent autoproteolysis activity, IUBMB Life, 73, 418-431. https://doi.org/10.1002/iub.2439

Chung-Chi Liao, Sahana Shankar, Wen-Chieh Pi, Chih-Chia Chang, Golam Rizvee Ahmed, Wei-Yi Chen and Kuo-Chiang Hsia, 2020, Karyopherin Kap114p-mediated trans-repression controls ribosomal gene expression undersaline stress, EMBO Report, e48324. DOI:10.15252/embr.201948324 * also listed in publications using iTC200.

Yuan-Chao Lou, Chun-Chi Chou, Hsin-Hong Yeh, Chia-Yu Chien, Sushant Sadotra, Chun-Hua Hsu and Chinpan Chen, 2020, Structural basis for −35 element recognition by σ4chimeraproteins and their interactions with PmrA response regulator, Proteins, 88, 69. https://doi.org/10.1002/prot.25768 * also listed in publications using CD and iTC200.

Cheng-Chung Lee, Ta-Wei Lin, Tzu-Ping Ko, and Andrew H.-J. Wang, 2020, Structural basis of polyethylene glycol recognition by antibody, J Biomed. Sci., 27, 12. doi: 10.1186/s12929-019-0589-7

Wei-Cheng Huang, Jiahn-Haur Liao, Tzu-Chun Hsiao, Tong-You Wade Wei, Manuel Maestre-Reyna, Yoshitaka Bessho and Ming-Daw Tsai, 2019, Binding and Enhanced Binding between Key Immunity Proteins TRAF6 and TIFA, ChemBioChem, 20, 140-146. DOI: 10.1002/cbic.201800436

Tesmine Martin, Yuan-Chao Lou, Chun-Chi Chou, Shu-Yi Wei, Sushant Sadotra, Chao-Cheng Cho, Meng-Hsuan Lin, Jung-Hsiang Tai, Chun-Hua Hsu and Chinpan Chen 2018, Structural basis of interaction between dimeric cyclophilin 1 and Myb1 transcription factor in Trichomonas vaginalis, Sci Rep., 8, 5410. DOI:10.1038/s41598-018-23821-5

Hui-Chuan Chang, Camy C.-H. Kung, Tzu-Ting Chang, Shu-Chuan Jao, Yu-Ting Hsu and Wen-Shan Li 2018, Investigation of the proton relay system operative in human cystosolic aminopeptidase P, PLoS One, 13(1), e0190816.

I-Ming Lee, I-Fan Tu, Feng-Ling Yang, Tzu-Ping Ko, Jiahn-Haur Liao, Nien-Tsung Lin, Chung-Yi Wu, Chien-Tai Ren, Andrew H.-J. Wang, Ching-Ming Chang, Kai-Fa Huang, and Shih-Hsiung Wu 2017, Structural basis for fragmenting the exopolysaccharide of Acinetobacter baumannii by bacteriophage ΦAB6 tailspike protein, Sci Rep., 7, 42711.

Hsin-Yi Yeh, Sheng-Wei Lin, Yi-Chun Wu, Nei-Li Chan and Peter Chi, 2017, Functional characterization of the meiosis-specific DNA double-strand break inducing factor SPO-11 from C. elegans, Sci Rep., 7, 2370. DOI:10.1038/s41598-017-02641-z

Yueh-Te Chan, Tzu-Ping Ko, Shan-Hsueh Yao, Ya-Wen Chen, Cheng-Chung Lee, and Andrew H.-J. Wang, 2017, Crystal Structure and Potential Head-to-Middle Condensation Function of a Z,Z-Farnesyl Diphosphate Synthase, ACS Omega, 2(3), 930–936.

Jiahn-Haur Liao, Chih-Ta Henry Chien, Han-Ying Wu, Kai-Fa Huang, Iren Wang, Meng-Ru Ho, I-Fan Tu, I-Ming Lee, Wei Li, Yu-Ling Shih, Chung-Yi Wu, Pavel A. Lukyanov, Shang-Te Danny Hsu, and Shih-Hsiung Wu 2016, A Multivalent Marine Lectin from Crenomytilus grayanus Possesses Anti-cancer Activity through Recognizing Globotriose Gb3, J. Am. Chem. Soc., 138(14), 4787–4795. * also listed in publications using Octet RED96.

Jui-Hung Weng, Yin-Cheng Hsieh, Chia-Chi Flora Huang, Tong-You Wade Wei, Liang-Hin Lim, Yu-Hou Chen, Meng-Ru Ho, Iren Wang†, Kai-Fa Huang, Chun-Jung Chen, and Ming-Daw Tsai 2015, Uncovering the Mechanism of Forkhead-Associated Domain-Mediated TIFA Oligomerization That Plays a Central Role in Immune Responses, Biochemistry, 54(40), 6219–6229. * also listed in publications using ITC and Octet RED96.

Huaying Zhao and Peter Schuck, et al. 2015, A Multilaboratory Comparison of Calibration Accuracy and the Performance of External References in Analytical Ultracentrifugation, PLoS One, 10(5), e0126420.

Che Yang, Wei-Lin Lo, Yun-Hsuan Kuo, Jason C. Sang, Chung-Yu Lee, Yun-Wei Chiang, and Rita P.-Y. Chen, 2015, Revealing Structural Changes of Prion Protein during Conversion from α-Helical Monomer to β-Oligomers by Means of ESR and Nanochannel Encapsulation, ACS Chem. Biol., 10, 493–501.

Yi-Hung Yeh, Tai-Wen Lin, Yi-Chuan Li, Jung-Yu Tung, Cheng-Yuan Lin and Chwan-Deng Hsiao, 2014, Structural and Functional Characterization of Ybr137wp Implicates Its Involvement in the Targeting of Tail-Anchored Proteins to Membranes, Mol. Cell. Biol., 34, 4500-4512.

Chun-Han Ho, Hao-Ching Wang, Tzu-Ping Ko, Yuan-Chih Chang, and Andrew H.-J. Wang, 2014, The T4 Phage DNA Mimic Protein Arn Inhibits the DNA Binding Activity of the Bacterial Histone-like Protein H-NS, J. Biol. Chem., 289, 27046-27054.

Cheng-Chung Lee, Li-Ling Lin, Woan-Eng Chan, Tzu-Ping Ko, Jiann-Shiun Lai and Andrew H.-J. Wang, 2013, Structural basis for the antibody neutralization of Herpes simplex virus, Acta Crystallographica Section D, D69, 1935-1945.

Jiahn-Haur Liao, Yu-Huan Sun, Chun-Hua Hsu, Yu-Ching Lin, Shih-Hsiung Wu, Chao-Jen Kuo, Chun-Hao Huang, Shyh-Horng Chiou, 2013, Up-regulation of neutrophil activating protein in Helicobacter pylori under high-salt stress: Structural and phylogenetic comparison with bacterial iron-binding ferritins, Biochimie, 95, 1136-1145.
* also listed in publications using ITC.

Cheng-Chung Lee, Ta-Wei Lin, Tzu-Ping Ko, and Andrew H.-J. Wang, 2011, The Hexameric Structures of Human Heat Shock Protein 90, PLoS ONE, 6(5), e19961.

Yu-Lin Tsai, Zi-Fu Wang, Wei-Wen Chen and Ta-Chau Chang, 2011, Emulsified BMVC derivative induced filtration for G-quadruplex DNA structural separation, Nucleic Acids Research, 39, e114.

Che-Chuan Yang, Yi-Ting Wang, Yu-Yuan Hsiao, Lyudmila G. Doudeva, Pan-Hsien Kuo, Sih Yao Chow and Hanna S. Yuan, 2010, Structural and biochemical characterization of CRN-5 and Rrp46: An exosome component participating in apoptotic DNA degradation, RNA, 16, 1748-1759.

Hui-Ju Chen, Tzu-Ping Ko, Chia-Yin Lee, Nai-Chen Wang and Andrew H.-J. Wang, 2009, Structure, Assembly, and Mechanism of a PLP-Dependent Dodecameric L-Aspartate beta-Decarboxylase, Structure, 17, 517-529.

BLI (GatorPlus, GatorBio)

Athira Saju, Po-Pang Chen, Tzu-Han Weng, Su-Yi Tsai, Akihiro Tanaka, Yu-Ting Tseng, Chih-Chia Chang, Chun-Hsiung Wang, Yuta Shimamoto and Kuo-Chiang Hsia, 2024, HURP binding to the vinca domain of β-tubulin accounts for cancer drug resistance, Nature Communications, 15: 8844. https://doi.org/10.1038/s41467-024-53139-y * also listed in publications using AUC.

BLI (Octet RED96, ForteBIO)

Yi-Hsuan Chang, Min-Feng Hsu, Wei-Nan Chen, Min-Hao Wu, Wye-Lup Kong, Mei-Yeh Jade Lu, Chih-Heng Huang, Fang-Ju Chang, Lan-Yi Chang, Ho-Yang Tsai, Chao-Ping Tung, Jou-Hui Yu, Yali Kuo, Yu-Chi Chou, Li-Yang Bai, Yuan-Chih Chang, An-Yu Chen, Cheng-Cheung Chen, Yi-Hua Chen, Chun-Che Liao, Chih-Shin Chang, Jian-Jong Liang, Yi-Ling Lin, Takashi Angata, Shang-Te Danny Hsu, and Kuo-I Lin, 2024, Functional and structural investigation of a broadly neutralizing SARS-CoV-2 antibody, JCI Insight 9(10), e179726. https://doi.org/10.1172/jci.insight.179726.

Kao, Hsi-Wen, Lu, Wei-Lin, Ho, Meng-Ru, Lin, Yu-Fong, Hsieh, Yun-Jung, Ko, Tzu-Ping, Danny Hsu, Shang-Te, and Wu, Kuen-Phon, 2023, Robust Design of Effective Allosteric Activators for Rsp5 E3 Ligase Using the Machine Learning Tool ProteinMPNN, ACS Synth Biol 12, 2310-2319.
*also listed in publications using iTC200.

Hung, Ta I, Hsieh, Yun-Jung, Lu, Wei-Lin, Wu, Kuen-Phon, and Chang, Chia-En A, 2023, What Strengthens Protein-Protein Interactions: Analysis and Applications of Residue Correlation Networks, J Mol Biol 435, 168337.

Huang, Kuan-Ying A, Chen, Xiaorui, Mohapatra, Arpita, Nguyen, Hong Thuy Vy, Schimanski, Lisa, Tan, Tiong Kit, Rijal, Pramila, Vester, Susan K, Hills, Rory A, Howarth, Mark, Keeffe, Jennifer R, Cohen, Alexander A, Kakutani, Leesa M, Wu, Yi-Min, Shahed-Al-Mahmud, Md, Chou, Yu-Chi, Bjorkman, Pamela J, Townsend, Alain R, and Ma, Che, 2023, Structural basis for a conserved neutralization epitope on the receptor-binding domain of SARS-CoV-2, Nat Commun 14, 311.

Ming-Chieh Chou, Yi-Hsuan Wang, Fei-Yun Chen, Chun-Ying Kung, Kuen-Phon Wu, Jean-Cheng Kuo, Shu-Jou Chan, Mei-Ling Cheng, Chih-Yu Lin, Yu-Chi Chou, Meng-Chiao Ho, Steven Firestine, Jie-Rong Huang and Ruey-Hwa Chen, 2023, PAICS ubiquitination recruits UBAP2 to trigger phase separation for purinosome assembly, Mol Cell 83, 4123-4140 e4112.

Chun-Chi Chou , Kuo-Tai Hua, Min-Wei Chen, Chin-Jui Wu, Chun-Hua Hsu, Jann-Tay Wang, Michael Hsiao, and Lin-Hung Wei, 2022, Discovery and characterization of a monoclonal antibody targeting a conformational epitope of IL-6/IL-6Ralpha to inhibit IL-6/ IL-6Ralpha/gp130 hexameric signaling complex formation, MAbs 14, 2029675. DOI: 10.1080/19420862.2022.2029675

Tzu-Han Lo, Hung-Lin Chen, Cheng-I Yao, I-Chun Weng, Chi-Shan Li, Chi-Chun Huang, Nien-Jung Chen, Chun-Hung Li, and Fu-Tong Liu, 2021, Galectin-3 promotes noncanonical inflammasome activation through intracellular binding to lipopolysaccharide glycans, PNAS, 118(30), e2026246118. https://doi.org/10.1073/pnas.2026246118

Tzu-Jing Yang, Pei-Yu Yu, Yuan-Chih Chang, Kang-Hao Liang, Hsian-Cheng Tso, Meng-Ru Ho, Wan-Yu Chen, Hsiu-Ting Lin, Han-Chung Wu and Shang-Te Danny Hsu, 2021, Effect of SARS-CoV-2 B.1.1.7 mutations on spike protein structure and function, Nature Structural & Molecular Biology, 28, 731-739.

Sushant Sadotra, Yuan-Chao Lou, Hao-Cheng Tang, Yi-Chih Chiu, Chun-Hua Hsu and Chinpan Chen, 2021, Structural basis for promoter DNA recognition by the response regulator OmpR, Journal of Structural Biology, 213(1), 107638. *also listed in publications using Chirascan+ qCD.

Yao-Hsiang Shih, Ling-Hsien Tu, Ting-Yu Chang, Kiruthika Ganesan, Wei-Wei Chang, Pao-Sheng Chang, Yu-Sheng Fang, Yeh-Tung Lin, Lee-Way Jin and Yun-Ru Chen, 2020, TDP-43 interacts with amyloid-β, inhibits fibrillization, and worsens pathology in a model of Alzheimer’s disease, Nat. Commun., 11, 5950. https://doi.org/10.1038/s41467-020-19786-7

Chih-Ta Henry Chien, Meng-Ru Ho, Chung-Hung Lin and Shang-Te Danny Hsu, 2017, Lactose Binding Induces Opposing Dynamics Changes in Human Galectins Revealed by NMR-Based Hydrogen–Deuterium Exchange, Molecules, 22, 1357.

Chia-Lin Chen, Jen-Chi Hsu, Chin-Wei Lin, Chia-Hung Wang, Ming-Hung Tsai, Chung-Yi Wu, Chi-Huey Wong, and Che Ma, 2017, Crystal Structure of a Homogeneous IgG-Fc Glycoform with the N-Glycan Designed to Maximize the Antibody Dependent Cellular Cytotoxicity, ACS Chem. Biol., 12, 1335-1345.

Chun-Chi Chou, Shu-Yi Wei, Yuan-Chao Lou and Chinpan Chen, 2017, In-depth study of DNA binding of Cys2His2 finger domains in testis zinc-finger protein, PLoS ONE, https://doi.org/10.1371/journal.pone.0175051.

Tung-Ju Hsieh, Hsien-Ya Lin, Zhijay Tu, Ting-Chien Lin, Shang-Chuen Wu, Yu-Yao Tseng, Fu-Tong Liu, Shang-Te Danny Hsu, and Chun-Hung Lin, 2016, Dual thio-digalactoside-binding modes of human galectins as the structural basis for the design of potent and selective inhibitors, Sci Rep., 6, 29457. * also listed in publications using iTC.

Jiahn-Haur Liao, Chih-Ta Henry Chien, Han-Ying Wu, Kai-Fa Huang, Iren Wang, Meng-Ru Ho, I-Fan Tu, I-Ming Lee, Wei Li, Yu-Ling Shih, Chung-Yi Wu, Pavel A. Lukyanov, Shang-Te Danny Hsu, and Shih-Hsiung Wu 2016, A Multivalent Marine Lectin from Crenomytilus grayanus Possesses Anti-cancer Activity through Recognizing Globotriose Gb3, J. Am. Chem. Soc., 138(14), 4787–4795. * also listed in publications using AUC.

Zi-Fu Wang, Ming-Hao Li, Wei-Wen Chen, Shang-Te Danny Hsu and Ta-Chau Chang 2016, A novel transition pathway of ligand-induced topological conversion from hybrid forms to parallel forms of human telomeric G-quadruplexes, Nucl. Acids Res., 44(8), 3958–3968.

Jui-Hung Weng, Yin-Cheng Hsieh, Chia-Chi Flora Huang, Tong-You Wade Wei, Liang-Hin Lim, Yu-Hou Chen, Meng-Ru Ho, Iren Wang†, Kai-Fa Huang, Chun-Jung Chen, and Ming-Daw Tsai 2015, Uncovering the Mechanism of Forkhead-Associated Domain-Mediated TIFA Oligomerization That Plays a Central Role in Immune Responses, Biochemistry, 54(40), 6219–6229. * also listed in publications using AUC and ITC.

Tung-Ju Hsieh, Hsien-Ya Lin, Zhijay Tu, Bo-Shun Huang, Shang-Chuen Wu and Chun-Hung Lin, 2015, Structural Basis Underlying the Binding Preference of Human Galectins-1, -3 and -7 for Galβ1-3/4GlcNAc, PLoS ONE, DOI: 10.1371/journal.pone.0125946

CD (Chirascan+ qCD, Applied Photophysics)

Kumar Jangam Vikram, Tien-Sheng Tseng, Yuan-Chao Lou, Shu-Yi Wei, Tsung-Han Wu, Hao-Cheng Tang, Yi-Chih Chiu, Chun-Hua Hsu, and Chinpan Chen ,2022, Structural insights into DNA binding domain of vancomycin-resistance-associated response regulator in complex with its promoter DNA from Staphylococcus aureus, Protein Sci 31, e4286.DOI: 10.1002/pro.4286 * also listed in publications using AUC.

Sashank Agrawal, Monika Jain, Wei-Zen Yang and Hanna S. Yuan, 2020, Frontotemporal dementia-linked P112H mutation of TDP-43 induces protein structural change and impairs its RNA binding function, Protein Science, 30, 350-365. * also listed in publications using PEAQ-DSC & Tycho NT.6.

Sushant Sadotra, Yuan-Chao Lou, Hao-Cheng Tang, Yi-Chih Chiu, Chun-Hua Hsu and Chinpan Chen, 2020, Structural basis for promoter DNA recognition by the response regulator OmpR, Journal of Structural Biology, 213(1), 107638. *also listed in publications using Octet RED96.

Ping-Sheng Wu, Shu-Jung Lai, Kit-Man Fung and Tien-Sheng Tseng, 2020, Characterization of the structure–function relationship of a novel salt-resistant antimicrobial peptide, RR12, RSC Adv., 10, 23624-23631.

Yuan-Chao Lou, Chun-Chi Chou, Hsin-Hong Yeh, Chia-Yu Chien, Sushant Sadotra, Chun-Hua Hsu and Chinpan Chen, 2020, Structural basis for −35 element recognition by σ4chimeraproteins and their interactions with PmrA response regulator, Proteins, 88, 69. https://doi.org/10.1002/prot.25768 * also listed in publications using AUC and iTC200.

Carillo, Kathleen D., Chi-Jen Lo, Der-Lii M. Tzou, Yi-Hung Lin, Shang-Ting Fang, Shu-Hsiang Huang, and Yi-Cheng Chen, 2020, The effect of calcium and halide ions on the gramicidin A molecular state and antimicrobial activity, International Journal of Molecular Sciences, 21, 6177.

Minh Thu, Tran Thi, Shu-Hsiang Huang, Ly Anh Tu, Shang-Ting Fang, Mai Suan Li, and Yi-Cheng Chen, 2019, G37V mutation of Aβ42 induces a nontoxic ellipse-like aggregate: An in vitro and in silico study, Neurochemistry International, 129, 104512.

Sashank Agrawal, Pan-Hsien Kuo, Lee-Ya Chu, Bagher Golzarroshan, Monika Jain and Hanna S. Yuan, 2019, RNA recognition motifs of disease-linked RNA-binding proteins contribute to amyloid formation, Scientific Reports, 9, 6171.

Tien-Sheng Tseng, Keng-Chang Tsai and Chinpan Chen, 2017, Characterizing the structure–function relationship reveals the mode of action of a novel antimicrobial peptide, P1, from jumper ant Myrmecia pilosul, Mol. BioSyst., 13, 1193-1201.

DLS (DynaPro NanoStar, Wyatt)

Hsin-Hung Lin, Chun-Hsiung Wang, Shih-Hsin Huang, Sung-Yao Lin, Takayuki Kato, Keiichi Namba, Naoki Hosogi, Chihong Song, Kazuyoshi Murata, Ching-Hsuan Yen, Tsui-Ling Hsu, Chi-Huey Wong, Yi-Min Wu, I.-Ping Tu and Wei-Hau Chang, 2024, Use of phase plate cryo-EM reveals conformation diversity of therapeutic IgG with 50 kDa Fab fragment resolved below 6 Å, Scientific Reports, 14, 14079.
https://doi.org/10.1038/s41598-024-62045-8

DSC (PEAQ-DSC Automatic and VP-Cap DSC, Malvern)

Puri, Sarita, Liu, Cheng-Yu, Hu, I-Chen, Lai, Chih-Hsuan, Hsu, Shang-Te Danny, and Lyu, Ping-Chiang,2023, Elucidation of the folding pathway of a circular permutant of topologically knotted YbeA by tryptophan substitutions, Biochem Biophys Res Commun 672, 81-88.

Puri Sarita, Szu-Ni Chen, Yi-Hsiang Chiu, Piotr Draczkowski, Kuang-Ting Ko, Tzu-Jing Yang, Yong-Sheng Wang, Susumu Uchiyama, and Shang-Te Danny Hsu 2022. Impacts of Cancer-associated Mutations on the Structure-Activity Relationship of BAP1, J Mol Biol 434, 167553. DOI: 10.1016/j.jmb.2022.167553

Tzu-Jing Yang, Pei-Yu Yu, Yuan-Chih Chang, Shang-Te Danny Hsu, 2021, D614G mutation in the SARS-CoV-2 spike protein enhances viral fitness by desensitizing it to temperature-dependent denaturation, J. Biol. Chem, 297(4), 101238. * also listed in publications using Tycho NT.6.

Sashank Agrawal, Monika Jain, Wei-Zen Yang and Hanna S. Yuan, 2020, Frontotemporal dementia-linked P112H mutation of TDP-43 induces protein structural change and impairs its RNA binding function, Protein Science, 30, 350-365. * also listed in publications using Chirascan+ qCD & Tycho NT.6.

Chu-Ya Wu, I-Chen Hu, Yi-Chen Yang, Wei-Cheng Ding, Chih-Hsuan Lai, Yi-Zong Lee1, Yi-Chung Liu, Hui-Chun Cheng and Ping-Chiang Lyu, 2020, An essential role of acetyl coenzyme A in the catalytic cycle of insect arylalkylamine N-acetyltransferase, COMMUNICATIONS BIOLOGY, 3, 441. https://doi.org/10.1038/s42003-020-01177-9

Kuang-Ting Ko, I. Chen Hu, Kai-Fa Huang, Ping-Chiang Lyu, and Shang-Te Danny Hsu, 2019, Untying a Knotted SPOUT RNA Methyltransferase by Circular Permutation Results in a Domain-Swapped Dimer, Structure, 27(8), 1224. https://doi.org/10.1016/j.str.2019.04.004 * also listed in publications using iTC200.

Manoj Kumar Sriramoju, Yen Chen, Yun-Tzai Cloud Lee and Shang-Te Danny Hsu, 2018, Topologically knotted deubiquitinases exhibit unprecedented mechanostability to withstand the proteolysis by an AAA+ protease, Sci Rep., 8, 7076.

DSF (Tycho NT.6, NanoTemper)

Ting-Juan Ye, Kai-Fa Huang, Tzu-Ping Ko, and Shih-Hsiung Wu, 2022, Synergic action of an inserted carbohydrate-binding module in a glycoside hydrolase family 5 endoglucanase, Acta Crystallogr D Struct Biol 78, 633-646. DOI: 10.1107/S2059798322002601* also listed in publications using PEAQ-iTC.

Singh Jai Prakash, Meng-Jung Lin, Shu-Fang Hsu, Wolfgang Peti, Cheng-Chung Lee, and Tzu-Ching Meng, 2021, Crystal Structure of TCPTP Unravels an Allosteric Regulatory Role of Helix alpha7 in Phosphatase Activity, Biochemistry 60, 3856-3867.

Sashank Agrawal, Monika Jain, Wei-Zen Yang and Hanna S. Yuan, 2021, Frontotemporal dementia-linked P112H mutation of TDP-43 induces protein structural change and impairs its RNA binding function, Protein Science, 30, 350-365. * also listed in publications using PEAQ-DSC & Chirascan+ qCD.

Tzu-Jing Yang, Pei-Yu Yu, Yuan-Chih Chang, Shang-Te Danny Hsu, 2021, D614G mutation in the SARS-CoV-2 spike protein enhances viral fitness by desensitizing it to temperature-dependent denaturation, J. Biol. Chem, 297(4), 101238. * also listed in publications using PEAQ-DSC.

ITC (iTC200 and PEAQ-ITC Automatic, Malvern)

(PEAQ-ITC Automatic) Po-Yin Chen, Yung-Chih Chen, Po-Pang Chen, Kuan-Ting Lin, Karen Sargsyan, Chao-Ping Hsu, Wei-Le Wang, Kuo-Chiang Hsia and See-Yeun Ting, 2024, A whole-cell platform for discovering synthetic cell adhesion molecules in bacteria, Nature Communications, 15: 6568. https://doi.org/10.1038/s41467-024-51017-1

Shen Wang, Chun-Hsiang Huang, Te-Sheng Lin, Yi-Qi Yeh, Yun-Sheng Fan, Si-Wei Wang, Hsi-Ching Tseng, Shing-Jong Huang, Yu-Yang Chang, U-Ser Jeng, Chung-I Chang and Shiou-Ru Tzeng, 2024, Structural basis for recruitment of peptidoglycan endopeptidase MepS by lipoprotein NlpI, Nature Communications, 15, 5461. https://doi.org/10.1038/s41467-024-49552-y

Wesley Tien Chiang, Yao-Kai Chang, Wei-Han Hui, Shu-Wei Chang, Chen-Yi Liao, Yi-Chuan Chang, Chun-Jung Chen, Wei-Chen Wang, Chien-Chen Lai, Chun-Hsiung Wang, Siou-Ying Luo, Ya-Ping Huang, Shan-Ho Chou, Tzyy-Leng Horng, Ming-Hon Hou, Stephen P. Muench, Ren-Shiang Chen, Ming-Daw Tsai, and Nien-Jen Hu, 2024, Structural basis and synergism of ATP and Na⁺ activation in bacterial K⁺ uptake system KtrAB, Nature Communications, 15, 3850. https://doi.org/10.1038/s41467-024-48057-y

(PEAQ-ITC Automatic) Sriramoju, Manoj Kumar, Ko, Kuang-Ting, and Hsu, Shang-Te Danny, 2024, Tying a true topological protein knot by cyclization, Biochem Biophys Res Commun 696, 149470.

Lou, Yuan-Chao, Tu, Cheng-Fen, Chou, Chun-Chi, Yeh, Hsin-Hong, Chien, Chia-Yu, Sadotra, Sushant, Chen, Chinpan, Yang, Ruey-Bing, and Hsu, Chun-Hua, 2024, Structural insights into the role of N-terminal integrity in PhoSL for core-fucosylated N-glycan recognition, Int J Biol Macromol 255, 128309. *also listed in publications using AUC.

(PEAQ-ITC Automatic) Wang, Yi-Shiang, Huang, Chun-Hsiang, Liou, Gunn-Guang, Hsueh, Hsueh-Wen, Liang, Chi-Ting, Tseng, Hsi-Ching, Huang, Shing-Jong, Chao, Chi-Chao, Hsieh, Sung-Tsang, and Tzeng, Shiou-Ru, 2023, A molecular basis for tetramer destabilization and aggregation of transthyretin Ala97Ser, Protein Sci 32, e4610.

Hsiu-Jung Wang, Víctor M Hernández-Rocamora, Chiao-I Kuo, Kan-Yen Hsieh, Szu-Hui Lee, Meng-Ru Ho, Zhijay Tu, Waldemar Vollmer, and Chang, Chung-I, 2023, Structural basis for the hydrolytic activity of the transpeptidase-like protein DpaA to detach Braun's lipoprotein from peptidoglycan, mBio 14, e0137923.

Liao, Chung-Chi, Wang, Yi-Sen, Pi, Wen-Chieh, Wang, Chun-Hsiung, Wu, Yi-Min, Chen, Wei-Yi, and Hsia, Kuo-Chiang, 2023, Structural convergence endows nuclear transport receptor Kap114p with a transcriptional repressor function toward TATA-binding protein, Nat Commun 14, 5518.

Kao, Hsi-Wen, Lu, Wei-Lin, Ho, Meng-Ru, Lin, Yu-Fong, Hsieh, Yun-Jung, Ko, Tzu-Ping, Danny Hsu, Shang-Te, and Wu, Kuen-Phon, 2023, Robust Design of Effective Allosteric Activators for Rsp5 E3 Ligase Using the Machine Learning Tool ProteinMPNN, ACS Synth Biol 12, 2310-2319. *also listed in publications using octet.

(PEAQ-ITC Automatic) Ting-Juan Ye, Kai-Fa Huang, Tzu-Ping Ko, and Shih-Hsiung Wu, 2022, Synergic action of an inserted carbohydrate-binding module in a glycoside hydrolase family 5 endoglucanase, Acta Crystallogr D Struct Biol 78, 633-646. DOI: 10.1107/S2059798322002601 * also listed in publications using Tycho.

(PEAQ-ITC Automatic) Po-Jung Pao,Min-Feng Hsu, Ming-Hui Chiang, Chun-Ting Chen, Cheng-Chung Lee, Andrew H.-J. Wang, 2021, Structural basis of an epitope tagging system derived from Haloarcula marismortui bacteriorhodopsin I D94N and its monoclonal antibody GD-26, The FEBS Journal, published on web. https://doi.org/10.1111/febs.16184

Hsien-Ya Lin, Chia-Yu Chen, Ting-Chien Lin, Lun-Fu Yeh, Wei-Che Hsieh, Shijay Gao, Pierre-Alain Burnouf, Bing-Mae Chen, Tung-Ju Hsieh, Punsaldulam Dashnyam, Yen-Hsi Kuo, Zhijay Tu, Steve R. Roffler and Chun-Hung Lin, 2021, Entropy-driven binding of gut bacterial β-glucuronidase inhibitors ameliorates irinotecan-induced toxicity, Communications Biology, 4, 280. https://doi.org/10.1038/s42003-021-01815-w

Chung-Chi Liao, Sahana Shankar, Wen-Chieh Pi, Chih-Chia Chang, Golam Rizvee Ahmed, Wei-Yi Chen and Kuo-Chiang Hsia, 2020, Karyopherin Kap114p-mediated trans-repression controls ribosomal gene expression undersaline stress, EMBO Report, e48324. DOI:10.15252/embr.201948324 * also listed in publications using AUC.

Yuan-Chao Lou, Chun-Chi Chou, Hsin-Hong Yeh, Chia-Yu Chien, Sushant Sadotra, Chun-Hua Hsu and Chinpan Chen, 2020, Structural basis for −35 element recognition by σ4chimeraproteins and their interactions with PmrA response regulator, Proteins, 88, 69. https://doi.org/10.1002/prot.25768 * also listed in publications using AUC and CD.

Chih-Chia Chang, Ching-Jou Chen, Cédric Grauffel, Yu-Chung Pien, Carmay Lim, Su-Yi Tsai and Kuo-Chiang Hsia, 2019, Ran pathway-independent regulation of mitotic Golgi disassembly by Importin-α, Nat. Commun., 10, 4307. https://doi.org/10.1038/s41467-019-12207-4

Kuang-Ting Ko, I. Chen Hu, Kai-Fa Huang, Ping-Chiang Lyu, and Shang-Te Danny Hsu, 2019, Untying a Knotted SPOUT RNA Methyltransferase by Circular Permutation Results in a Domain-Swapped Dimer, Structure, 27(8), 1224. https://doi.org/10.1016/j.str.2019.04.004 * also listed in publications using PEAQ-DSC.

Yao-Kai Chang, Ya-Ping Huang, Xiao-Xia Liu, Tzu-Ping Ko, Yoshitaka Bessho, Yoshiaki Kawano, Manuel Maestre-Reyna, Wen-Jin Wu, and Ming-Daw Tsai, 2019, Human DNA Polymerase μ Can Use a Noncanonical Mechanism for Multiple Mn²⁺-Mediated Functions, J. Am. Chem. Soc., DOI: 10.1021/jacs.9b01741

Chih-Cheng Lin, Ya-Ting Chao, Wan-Chieh Chen, Hsiu-Yin Ho, Mei-Yi Chou, Ya-Ru Li, Yu-Lin Wu, Hung-An Yang, Hsiang Hsieh, Choun-Sea Lin, Fu-Hui Wu, Shu-Jen Chou, Hao-Chung Jen, Yung-Hsiang Huang, Deli Irene, Wen-Jin Wu, Jian-Li Wu, Daniel J. Gibbs, Meng-Chiao Ho and Ming-Che Shih, 2019, Regulatory cascade involving transcriptional and N-end rule pathways in rice under submergence, PNAS, 116(8), 3300-3309.

Shin-Jen Lin, Yi-Fan Chen, Kai-Cheng Hsu,Yun-Ling Chen, Tzu-Ping Ko, Chu-Fang Lo, Han-Ching Wang and Hao-Ching Wang, 2019, Structural Insights to the Heterotetrameric Interaction between the Vibrio parahaemolyticus PirAvp and PirBvp Toxins and Activation of the Cry-Like Pore-Forming Domain, Toxin, 11, 233. doi:10.3390/toxins11040233

Ming-Fen Huang, Shin-Jen Lin, Tzu-Ping Ko, Yi-Ting Liao, Kai-Cheng Hsu, Hao-Ching Wang, 2017, The monomeric form of Neisseria DNA mimic protein DMP19 prevents DNA from binding to the histone-like HU protein, PLoS ONE, 12(12), e0189461.

Yun-Tzai Cloud Lee, Chia-Yun Chang, Szu-Yu Chen, Yun-Ru Pan, Meng-Ru Ho and Shang-Te Danny Hsu, 2017, Entropic stabilization of a deubiquitinase provides conformational plasticity and slow unfolding kinetics beneficial for functioning on the proteasome, Sci Rep., 7, 45174.

Tung-Ju Hsieh, Hsien-Ya Lin, Zhijay Tu, Ting-Chien Lin, Shang-Chuen Wu, Yu-Yao Tseng, Fu-Tong Liu, Shang-Te Danny Hsu, and Chun-Hung Lin, 2016, Dual thio-digalactoside-binding modes of human galectins as the structural basis for the design of potent and selective inhibitors, Sci Rep., 6, 29457. * also listed in publications using Octet RED96.
Mu-Sen Liu, Hsin-Yue Tsai, Xiao-Xia Liu, Meng-Chiao Ho, Wen-Jin Wu, and Ming-Daw Tsai, 2016, Structural Mechanism for the Fidelity Modulation of DNA Polymerase λ, J. Am. Chem. Soc., 138, 2389-2398.

Jui-Hung Weng, Yin-Cheng Hsieh, Chia-Chi Flora Huang, Tong-You Wade Wei, Liang-Hin Lim, Yu-Hou Chen, Meng-Ru Ho, Iren Wang†, Kai-Fa Huang, Chun-Jung Chen, and Ming-Daw Tsai 2015, Uncovering the Mechanism of Forkhead-Associated Domain-Mediated TIFA Oligomerization That Plays a Central Role in Immune Responses, Biochemistry, 54(40), 6219–6229. * also listed in publications using AUC and Octet RED96.

Jiahn Haur Liao, Tzu Hua Wu, Ming Yi Chen, Wei Ting Chen, Shou Yun Lu, Yi Hsuan Wang, Shao Pin Wang, Yen Min Hsu, Yi Shiang Huang, Zih You Huang, Yu Ching Lin, Ching Ming Chang, Fu Yung Huang and Shih Hsiung Wu, 2015, The Comparative Studies of Binding Activity of Curcumin and Didemethylated Curcumin with Selenite: Hydrogen Bonding vs Acid-Base Interactions, Scientific Reports, 5, 17614.

Yi-Chuan Li, Chung-ke Chang, Chi-Fon Chang, Ya-Hsin Cheng, Pei-Ju Fang, Tsunai Yu, Sheng-Chia Chen, Yi-Ching Li, Chwan-Deng Hsiao, and Tai-huang Huang, 2014, Structural dynamics of the two-component response regulator RstA in recognition of promoter DNA element, Nucl. Acids Res., 42, 8777-8788.

Yuan-Chao Lou, Iren Wang, M. Rajasekaran, Yi-Fen Kao, Meng-Ru Ho, Shang-Te Danny Hsu, Shan-Ho Chou, Shih-Hsiung Wu, and Chinpan Chen, 2014, Solution structure and tandem DNA recognition of the C-terminal effector domain of PmrA from Klebsiella pneumoniae, Nucl. Acids Res., 42, 4080-4093. * also listed in publications using CD.

Jiahn-Haur Liao, Yu-Huan Sun, Chun-Hua Hsu, Yu-Ching Lin, Shih-Hsiung Wu, Chao-Jen Kuo, Chun-Hao Huang, Shyh-Horng Chiou, 2013, Up-regulation of neutrophil activating protein in Helicobacter pylori under high-salt stress: Structural and phylogenetic comparison with bacterial iron-binding ferritins, Biochimie, 95, 1136-1145.
* also listed in publications using AUC.

Jiahn-Haur Liao,Chiao-I Kuo,Ya-Yi Huang,Yu-Ching Lin,Yen-Chen Lin,Chen-Yui Yang, Wan-Ling Wu, Wei-Hau Chang, Yen-Chywan Liaw, Li-Hua Lin, Chung-I Chang, Shih-Hsiung Wu, 2012, A Lon-like protease with no ATP-powered unfolding activity, PLoS ONE, 7(7), e40226.

Shu-Yi Wei, Yuan-Chao Lou, Jia-Yin Tsai, Meng-Ru Ho, Chun-Chi Chou, M. Rajasekaran, Hong-Ming Hsu, Jung-Hsiang Tai, Chwan-Deng Hsiao, and Chinpan Chen, 2012, Structure of the Trichomonas vaginalis Myb3 DNA-binding domain bound to a promoter sequence reveals a unique C-terminal β-hairpin conformation, Nucl. Acids Res., 40, 449-460.

Tzu-Huei Kao, Yeh Chen, Chien-Hua Pai, Ming-Chung Chang and Andrew H.-J. Wang, 2011, Structure of a NADPH-dependent blue fluorescent protein revealed the unique role of Gly176 on the fluorescence enhancement, Journal of Structural Biology, 174, 485-493.

Jiahn-Haur Liao, Chien-Sheng Chen, Chao-Chien Hu, Wei-Ting Chen, Shao-Pin Wang, I-Lin Lin, Yi-Han Huang, Ming-Hsuan Tsai, Tzu-Hua Wu, Fu-Yung Huang, and Shih-Hsiung Wu, 2011, Ditopic complexation of selenite anionsor calcium cations by pirenoxine: an implication for anti-cataractogenesis, Inorganic Chemistry, 50, 365-377.

Hsing-Mao Chu, Tzu-Ping Ko, and Andrew H.-J. Wang, 2010, Crystal structure and substrate specificity of plant adenylate isopentenyltransferase from Humulus lupulus: distinctive binding affinity for purine and pyrimidine nucleotides, Nucleic Acids Research, 38, 1738-1748.

Hsing-Mao Chu, Feng-Yuan Chen, Tzu-Ping Ko, and Andrew H.-J. Wang, 2010, Binding and catalysis of Humulus lupulus adenylate isopentenyltransferase for the synthesis of isopentenylated diadenosine polyphosphates, FEBS Lett., 584, 4083-4088.

MST (Monolith NT.115pico, NanoTemper)

Shekhar, Arvind Chandra, Wu, Wen-Jin, and Chen, Hung-Ta, 2023, Mutational and biophysical analyses reveal a TFIIIC binding region in the TFIIF-related Rpc53 subunit of RNA polymerase III, J Biol Chem 299, 104859

Shekhar, Arvind Chandra, Yuan-En Sun, Seok-Kooi Khoo, Yu-Chun Lin, Ester Betaria Malau, Wei-Hau Chang, and Hung-Ta Chen, 2022, Site-Directed Biochemical Analyses Reveal That the Switchable C-Terminus of Rpc31 Contributes to Rna Polymerase Iii Transcription Initiation, Nucleic Acids Research. DOI: 10.1093/nar/gkac1163

Shin-Tai Chen, Jiahn-Haur Liao, Kai-Fa Huang, I-Ming Lee, Wei-Ting Wong, Shih-Hsiung Wu and Kuo-Feng Hua, 2021, A GalNAc/Gal-specific lectin modulates immune responses via toll-like receptor 4 independently of carbohydrate-binding ability, Chem. Commun.57, 6209-6212. DOI: 10.1039/D1CC01834E

Yi-Ting Liao, Shin-Jen Lin, Tzu-Ping Ko, Chang-Yi Liu, Kai-Cheng Hsu and Hao-Ching Wang, 2020, Structural insight into the differential interactions between the DNA mimic protein SAUGI and two gamma herpesvirus uracil-DNA glycosylases, International Journal of Biological Macromolecules, 160, 903. DOI:10.1016/j.ijbiomac.2020.05.267

An-Shan Hsiao, Kuan Wang and Tuan-Hua David Ho, 2020, An intrinsically disordered protein interacts with the cytoskeleton for adaptive root growth under stress, Plant Physiology, 183, 570-587. DOI: 10.1104/pp.19.01372

Lee IM, Yang FL, Chen TL, Liao KS, Ren CT, Lin NT, Chang YP, Wu CY, Wu SH, 2018, Pseudaminic acid on exopolysaccharide of Acinetobacter baumannii plays a critical role in phage-assisted preparation of glycoconjugate vaccine with high antigenicity., J Am Chem Soc. , 140(28), 8639-8643.

Yu-Cheng Su, Pierre-Alain Burnouf, Kuo-Hsiang Chuang, Bing-Mae Chen, Tian-Lu Cheng and Steve R. Roffler, 2017,Conditional internalization of PEGylated nanomedicines by PEG engagers for triple negative breast cancer therapy, Nature Communications, 8, 15507. DOI: 10.1038/ncomms15507

Hsin-Yi Tung, Yu-Cheng Su, Bing-Mae Chen, Pierre-Alain Burnouf, Wei-Chiao Huang, Kuo-Hsiang Chuang, Yu-Ting Yan, Tian-Lu Cheng, and Steve R Roffler, 2015, Selective Delivery of PEGylated Compounds to Tumor Cells by anti-PEG Hybrid Antibodies, Mol. Cancer Ther., 14(6), 1317-1326. * also listed in publications using Biacore T200.

SPR (Biacore T200, GE Healthcare Life Sciences; Biacore 8K, Cytiva)

Yi-Han Tseng, Hsuan-Pei Lin, Sung-Yao Lin, Bing-Mae Chen, Thanh Nguyet Nguyen Vo, Shih-Hung Yang, Yi-Chen Lin, Zeljko Prijovic, Andreas Czosseck, Yu-Lin Leu and Steve R Roffler, 2024, Engineering stable and non-immunogenic immunoenzymes for cancer therapy via in situ generated prodrugs, Journal of Controlled Release, 369, 179-198. https://doi.org/10.1016/j.jconrel.2024.02.026

Lee, Cheng-Chung, Kuo, Wen-Chih, Chang, Ya-Wen, Hsu, Shu-Fang, Wu, Chia-Hung, Chen, Ya-Wen, Chang, Jui-Jen, and Wang, Andrew H-J,2023, Structure-Based Development of a Canine TNF-alpha-Specific Antibody Using Adalimumab as a Template, Protein Sci, 33, e4873.

(Biacore 8K) Shih-Chieh Su, Tzu-Jing Yang, Pei-Yu Yu, Kang-Hao Liang, Wan-Yu Chen, Chun-Wei Yang, Hsiu-Ting Lin, Mei-Jung Wang, Ruei-Min Lu, Hsien-Cheng Tso, Meng-Jhe Chung, Tzung-Yang Hsieh, Yu-Ling Chang, Shin-Chang Lin, FangYu Hsu, Feng-Yi Ke, Yi-Hsuan Wu, Yu-Chyi Hwang, I-Ju Liu, Jian-Jong Liang, Chun-Che Liao, Hui-Ying Ko, Cheng-Pu Sun, Ping-Yi Wu, Jia-Tsrong Jan, YuanChih Chang, Yi-Ling Lin, Mi-Hua Tao, Shang-Te Danny Hsu and Han-Chung Wu, 2021, Structure-guided antibody cocktail for prevention and treatment of COVID-19, PLOS Pathogens, Published on web.
https://doi.org/10.1371/journal.ppat.1009704

Wen-Chih Kuo, Cheng-Chung Lee, Ya-Wen Chang, Wei Pang, Hong-Sen Chen, Shin-Chen Hou, Shin-Yi Lo, An-Suei Yang and Andrew H.-J. Wang, 2021, Structure-based development of human interleukin-1β-specific antibody that simultaneously inhibits binding to both IL-1RI and IL-1RAcP, Journal of Molecular Biology, 433(4), 19.

Hajjaj H. M. Abdu-Allah, Shang-Chuen Wu, Chun-Hung Lin and Yu-Yao Tseng, 2020, Design, synthesis and molecular docking study of α-triazolylsialosides as non-hydrolyzable and potent CD22 ligands, European Journal of Medicinal Chemistry, 208, 112707. DOI: https://doi.org/10.1016/j.ejmech.2020.112707

Jheng-Syong Wu, Tzu-Yun Chen, Sam Song-Yao Lin, Shu-Yu Lin, Cheng-Yu Hung, I. Ping Tu, Hung-Ta Chen, and Wei-Hau Chang, 2019, Deriving a sub-nanomolar affinity peptide from TAP to enable smFRET analysis of RNA polymerase II complexes, Methods, 159-160, 59.

Ming-Shiu Lin, Tse-Ming Hong, Ting-Hung Chou, Shuenn-Chen Yang, Wei-Chia Chung, Chia-Wei Weng, Mei-Ling Tsai, Ting-Jen Rachel Cheng, Jeremy J. W. Chen, Te-Chang Lee, Chi-Huey Wong, Rong-Jie Chein, and Pan-Chyr Yang, 2019, 4(1H)-quinolone derivatives overcome acquired resistance to anti-microtubule agents by targeting the colchicine site of β-tubulin, European Journal of Medicinal Chemistry, 181, 111584.

Yi-Ting Liao, Shih-Shun Lin, Shin-Jen Lin, Wan-Ting Sun, Bing-Nan Shen, Han-Pin Cheng, Chan-Pin Lin, Tzu-Ping Ko, Yi-Fan Chen, and Hao-Ching Wang, 2019, Structural insights into the interaction between phytoplasmal effector causing phyllody 1 and MADS transcription factors, The Plant Journal, 100, 706.

Cheng-Chung Lee, Chih-Ya Yang, Li-Ling Lin, Tzu-Ping Ko, Alarng Hsun-Lang Chang, Stanley Shi-Chung Chang and Andrew H.-J. Wang, 2019, An Effective Neutralizing Antibody Against Influenza Virus H1N1 from Human B Cells, Scientific Reports, 9(1), 4546.

Min-Shao Tsai, Ming-Tsai Chiang, Dong-Lin Tsai, Chih-Wen Yang, Hsien-San Hou, Yi-Ru Li, Po-Chiao Chang, Heng-Huei Lin, Huan-Yuan Chen, Ing-Shouh Hwang, Pei-Kuen Wei, Chiao-Po Hsu, Kuo-I Lin, Fu-Tong Liu and Lee-Young Chau, 2019, Galectin-1 restricts vascular smooth muscle cell motility via modulating adhesion force and focal adhesion dynamics, Scientific Reports, 8, 11497. DOI:10.1038/s41598-018-29843-3

Ying-Chi Chao, Joerg Fleischer, Ruey-Bing Yang, 2018, Guanylyl cyclase-G is an alarm pheromone receptor in mice, The EMBO Journal, 37, 39-49. DOI 10.15252/embj.201797155

Hao-Ching Wang, Chun-Han Ho, Chia-Cheng Chou, Tzu-Ping Ko, Ming-Fen Huang, Kai-Cheng Hsu and Andrew H.-J. Wang, 2016, Using structural-based protein engineering to modulate the differential inhibition effects of SAUGI on human and HSV uracil DNA glycosylase, Nucl. Acids Res., 44, 4440-4449. DOI: 10.1093/nar/gkw185.

Chin-Wei Lin, Ming-Hung Tsai, Shiou-Ting Li, Tsung-I Tsai, Kuo-Ching Chu, Ying-Chih Liu, Meng-Yu Lai, Chia-Yu Wu, Yung-Chieh Tseng, Sachin S. Shivatare, Chia-Hung Wang, Ping Chao, Shi-Yun Wang, Hao-Wei Shih, Yi-Fang Zeng, Tsai-Hong You, Jung-Yu Liao, Yu-Chen Tu, Yih-Shyan Lin, Hong-Yang Chuang, Chia-Lin Chen, Charng-Sheng Tsai, Chiu-Chen Huang, Nan-Horng Lin, Che Ma, Chung-Yi Wu, and Chi-Huey Wong, 2015, A common glycan structure on immunoglobulin G for enhancement of effector functions, PNAS, 112, 10611-10616.

Hsin-Yi Tung, Yu-Cheng Su, Bing-Mae Chen, Pierre-Alain Burnouf, Wei-Chiao Huang, Kuo-Hsiang Chuang, Yu-Ting Yan, Tian-Lu Cheng, and Steve R Roffler, 2015, Selective Delivery of PEGylated Compounds to Tumor Cells by anti-PEG Hybrid Antibodies, Mol. Cancer Ther., 14(6), 1317-1326. * also listed in publications using MST.

Chia-Hsien Lin, Jung-Kuei Chen, Tai-Ming Ko, Chun-Yu Wei, Jer-Yuarn Wu, Wen-Hung Chung, Shih-Yang Chen, You-Di Liao, Shuen-Iu Hung, Yuan-Tsong Chen, 2014, Immunologic basis for allopurinol-induced severe cutaneous adverse reactions: HLA-B*58:01-restricted activation of drug-specific T cells and molecular interaction, J Allergy Clin Immunol, 135, 1063-1065.

Yu-Cheng Su, Talal S Al-Qaisi, Hsin-Yi Tung, Tian-Lu Cheng, Kuo-Hsiang Chuang, Bing-Mae Chen and Steve R Roffler, 2014, Mimicking the germinal center reaction in hybridoma cells to isolate temperature-selective anti-PEG antibodies., mAbs, 6, 1069-1083.
* also listed in publications using nano DSC III.

Chun-Yu Wei, Wen-Hung Chung, Hsiao-Wen Huang, Yuan-Tsong Chen and Shuen-Iu Hung, 2012, Direct interaction between HLA-B and carbamazepine activates T cells in patients with Stevens-Johnson syndrome, J Allergy Clin Immunol,, 129, 1562-1569.

Carmen Romera, Oriane Bombarde, Romaric Bonnet, Dennis Gomez, Pascal Dumy,Patrick Calsou, Jean-Fang Gwan, Jung-Hsin Lin, Eric Defrancq and Geneviève Pratviel, 2011, Improvement of porphyrins for G-quadruplex DNA targeting, Biochimie, 93, 1310-1317.

Teng-Hsu Wang, Yen-Lun Kung, Min-Hsiung Lee, and Nan-Wei Su, 2011, N-acetyl-D-galactosamine-specific lectin isolated from the seeds of Carica papaya, J. Agric. Food Chem., 59, 4217-4224.

Yu-Ching Lin, Huai-Cheng Lee, Iren Wang, Chun-Hua Hsu, Jiahn-Haur Liao, Alan Yueh-Luen Lee, Chinpan Chen and Shih-Hsiung Wu, 2009, DNA-binding specificity of the Lon protease [alpha]-domain from Brevibacillus thermoruber WR-249, Biochemical and Biophysical Research Communications, 388, 62-66.

CD (Aviv CD Model 202) (2008/10/1-2015/7/7)

Kuo Yuan Hwa, Boopathi Subramani, San-Tai Shen and Yu-May Lee, 2015, Exchange of active site residues alters substrate specificity in extremely thermostable beta-glycosidase from Thermococcus kodakarensis KOD1, Enzyme and Microbial Technology, 77, 14-20.

Iren Wang, Madzia P. Kowalski, Alexander R. Langley, Raphael Rodriguez, Shankar Balasubramanian, Shang-Te Danny Hsu, and Torsten Krude, 2014, Nucleotide Contributions to the Structural Integrity and DNA Replication Initiation Activity of Noncoding Y RNA, Biochemistry, 53, 5848-5863.

Yuan-Chao Lou, Iren Wang, M. Rajasekaran, Yi-Fen Kao, Meng-Ru Ho, Shang-Te Danny Hsu, Shan-Ho Chou, Shih-Hsiung Wu, and Chinpan Chen, 2014, Solution structure and tandem DNA recognition of the C-terminal effector domain of PmrA from Klebsiella pneumoniae, Nucl. Acids Res., 42, 4080-4093. * also listed in publications using iTC.

Jen-Fei Chu, Ta-Chau Chang, and Hung-Wen Li, 2010, Single-Molecule TPM Studies on the Conversion of Human Telomeric DNA, Biophysical Journal, 98, 1608-1616.

DLS (ZetaSizer Nano ZS, Malvern) (2008/01/23-2023/06/30)

Jo-Chu Tsou, Chun-Ju Tsou, Chun-Hsiung Wang, An-Li A. Ko, Yi-Hui Wang, Huan-Hsuan Liang, Jia-Cheng Sun, Kai-Fa Huang,Tzu-Ping Ko, Shu-Yu Lin and Yane-Shih Wang, 2024, Site-specific histidine aza-Michael addition in proteins enabled by a ferritin-based metalloenzyme, J. Am. Chem. Soc. 146, 49, 33309–33315. https://doi.org/10.1021/jacs.4c14446

Pei-Chi Huang, Shao-Kang Chen, Wei-Hung Chiang, Meng-Ru Ho, and Kuen-Phon Wu, 2022, Structural basis for the helical filament formation of Escherichia coli glutamine synthetase, Protein Sci 31, e4304. DOI: 10.1002/pro.4304

Wahyuningtyas Devi, Wen-Hao Chen, Ruei-Yu He, Yung-An Huang, Chia-Kang Tsao, Yu-Jung He, Chu-Yi Yu, Po-Chao Lu, Yu-Cai Chen, Sheng-Hann Wang, Ka Chon Ng, Bryan Po-Wen Chen, Pei-Kuen Wei, Jiun-Jie Shie, Chun-Hong Kuo, Y Henry Sun, and Joseph Jen-Tse Huang, 2021, Polyglutamine-Specific Gold Nanoparticle Complex Alleviates Mutant Huntingtin-Induced Toxicity, ACS Appl. Mater. Interfaces 13, 51, 60894–60906. https://doi.org/10.1021/acsami.1c18754.

Yi-Hui Wang, Mu-Lung Jian, Pei-Jung Chen, Jo-Chu Tsou, Le P Truong, and Yane-Shih Wang, 2021, Ferritin Conjugates With Multiple Clickable Amino Acids Encoded by C-Terminal Engineered Pyrrolysyl-tRNA Synthetase, Front Chem 9, 779976.

Pounraj Thanasekaran, Chih-Hang Chu, Sheng-Bo Wang, Kuan-Yu Chen, Hua-De Gao, Mandy M. Lee, Shih-Sheng Sun, Jui-Ping Li, Jiun-Yu Chen, Jen-Kun Chen, Yu-Hsu Chang, and Hsien-Ming Lee, 2019, Lipid-wrapped upconversion nanoconstruct/photosensitizer complex for near-infrared light-mediated photodynamic therapy, ACS Appl. Mater. Interfaces,11, 84-95. DOI: 10.1021/acsami.8b07760.

Pierre-Alain Burnouf, Yu-Lin Leu, Yu-Cheng Su, Kenneth Wu, Wei-Chi Lin and Steve R. Roffler, 2018, Reversible glycosidic switch for secure delivery of molecular nanocargos, Nature Communications, 9, 1843. DOI: 10.1038/s41467-018-04225-5.

Ruei-Yu He, Shu-Han Chao, Yu-Ju Tsai, Chi-Chang Lee, Chu-Yi Yu, Hua-De Gao, Yung-An Huang, Eric Hwang, Hsien-Ming Lee and Joseph Jen-Tse Huang, 2017, Photocontrollable probe spatiotemporally induces neurotoxic fibrillar aggregates and impairs nucleocytoplasmic trafficking, ACS Nano, 11, 6795-6807.DOI: 10.1021/acsnano.7b01645.

Rey Y. Capangpangan, Mira Anne C. dela Rosa, Rofeamor P. Obena, Yu-Jen Chou, Der-Lii Tzou, Shao-Ju Shih, Ming-Hsi Chiang, Chun-Cheng Lin and Yu-Ju Chen, 2015, Monodispersity of magnetic immuno-nanoprobes enhances the detection sensitivity of low abundance biomarkers in one drop of serum, Analys, 140, 7678-7686.

Chen-Wei Li, Kai-Wei Hon, Bhaswati Ghosh, Po-Han Li, Hsien-Ya Lin, Po-Han Chan, Chun-Hung Lin, Yu-Chie Chen and Kwok-Kong Tony Mong, 2014, Synthesis of oligomeric mannosides and their structure-binding relationship with concanavalin A, Chem. Asian J. , 9, 1786-1796.

Chun-Wei Chi, Yeh-Hsing Lao, Yi-Shan Li, Lin-Chi Chen, 2011, A quantum dot-aptamer beacon using a DNA intercalating dye as the FRET reporter: Application to label-free thrombin detection, Biosensors and Bioelectronics , 26, 3346-3352.

Chia-Ying Wu, Yi-Chun Yeh, Yu-Chih Yang, Ching Chou, Ming-Tsan Liu, Ho-Sheng Wu, Jia-Tsrong Chan and Pei-Wen Hsiao, 2010, Mammalian expression of virus-like particles for advanced mimicry of authentic influenza virus, PLoS ONE, 5(3), e9784.

DSC (Nano DSC III, TA Instuments) (2008/3/6-2016/12/31)

Chun-Ling Chang, Alexander S. Fridman, Roger M. Wartell, Chin-Kun Hua, Dmitri Y. Lando, 2017, Relationship between calorimetric profiles and differential melting curves for natural DNAs, International Journal of Biological Macromolecules, 102, 591-598.

Chun-Ling Chang, Chun-Chung Chen, Chin-Kun Hu, Dmitri Y. Lando, 2017, Second derivative techniques in differential scanning calorimetry of DNA modified with platinum compounds, Thermochimica Acta, 654, 186-190.

Dmitri Y. Landoa, Alexander S. Fridman, Chun-Ling Chang, Inessa E. Grigoryan, Elena N. Galyuk, Oleg N. Murashko, Chun-Chung Chen, and Chin-Kun Hu, 2015, Determination of melting temperature and temperature melting range for DNA with multi-peak differential melting curves, Analytical Biochemistry, 479, 28-36.

Margaret Hsin-Jui Kuo, Zi-Fu Wang, Ting-Yuan Tseng, MingHao Li, Shang-Te Danny Hsu, Jing-Jer Lin, and Ta-Chau Chang, 2015, Conformational Transition of a Hairpin Structure to G-Quadruplex within the WNT1 Gene Promoter, J. Am. Chem. Soc., 137, 210–218.

Yu-Cheng Su, Talal S Al-Qaisi, Hsin-Yi Tung, Tian-Lu Cheng, Kuo-Hsiang Chuang, Bing-Mae Chen and Steve R Roffler, 2014, Mimicking the germinal center reaction in hybridoma cells to isolate temperature-selective anti-PEG antibodies., mAbs, 6, 1069-1083.
* also listed in publications using Biacore T200.

Dmitri Y. Lando, Chun-Ling Chang, Alexander S. Fridman, Inessa E. Grigoryan, Elena N. Galyuk, Ya-Wei Hsueh and Chin-Kun Hu, 2014, Comparative thermal and thermodynamic study of DNA chemically modified with antitumor drug cisplatin and its inactive analog transplatin, J. Inorg. Biochem., accepted.

Ming-Hao Li, Zi-Fu Wang, Margaret Hsin-Jui Kuo, Shang-Te Danny Hsu, and Ta-Chau Chang, 2014, Unfolding kinetics of human telomeric G-quadruplexes studied by NMR spectroscopy, J. Phys. Chem. B, 118, 931-936.

Hung-Ju Chang, Jhih-Wei Jian, Hung-Ju Hsu, Yu-Ching Lee, Hong-Sen Chen, Jhong-Jhe You, Shin-Chen Hou, Chih-Yun Shao, Yen-Ju Chen, Kuo-Ping Chiu, Hung-Pin Peng, Kuo Hao Lee, and An-Suei Yang, 2014, Loop-sequence features and stability determinants in antibody variable domains by high-throughput experiments, Structure, 22, 9-21.

Hung-Ju Hsu, Kuo Hao Lee, Jhih-Wei Jian, Hung-Ju Chang, Chung-Ming Yu, Yu-Ching Lee, Ing-Chien Chen, Hung-Pin Peng, Chih Yuan Wu, Yu-Feng Huang, Chih-Yun Shao, Kuo Ping Chiu, and An-Suei Yang, 2014, Antibody variable domain interface and framework sequence requirements for stability and function by high-throughput experiments, Structure, 22, 22-34.

Zi-Fu Wang and Ta-Chau Chang, 2012, Molecular engineering of G-quadruplex ligands based on solvent effect of polyethylene glycol, Nucl. Acids Res, online: June 26. doi: 10.1093/nar/gks578

Inn-Ho Tsai, Hui-Ching Chang, Jin-Mei Chen, An-Chun Cheng and Kay Hooi Khoo, 2012, Glycan structures and intrageneric variations of venom acidic phospholipases A2 from Tropidolaemus pitvipers, FEBS J., 279, 2672-2682.

Chang-Ting Lin, Ting-Yuan Tseng, Zi-Fu Wang, and Ta-Chau Chang, 2011, Structural conversion of intramolecular and intermolecular G-quadruplexes of bcl2mid: The effect of potassium concentration and ion exchange, J. Phys. Chem. B, 115, 2360-2370.

(AUC, iTC200, Octet) Jui-Hung Weng, Yin-Cheng Hsieh, Chia-Chi Flora Huang, Tong-You Wade Wei, Liang-Hin Lim, Yu-Hou Chen, Meng-Ru Ho, Iren Wang, Kai-Fa Huang, Chun-Jung Chen, and Ming-Daw Tsai, 2015, Uncovering the Mechanism of Forkhead-Associated DomainMediated TIFA Oligomerization That Plays a Central Role in Immune Responses, Biochemistry, DOI: 10.1021/acs.biochem.5b00500

(iTC200) Jer-Sheng Lin, Hsin-Hui Wu, Pang-Hung Hsu, Lay-Sun Ma, Yin-Yuin Pang, Ming-Daw Tsai, Erh-Min Lai, 2014, Fha Interaction with Phosphothreonine of TssL Activates Type VI Secretion in Agrobacterium tumefaciens, PLoS Pathog., 10: e1003991.

(iTC200) Wen-Jin Wu, Mei-I Su, Jian-Li Wu, Sandeep Kumar, Liang-hin Lim, Chun-Wei Eric Wang, Frank H. T. Nelissen, Ming-Chuan Chad Chen, Jurgen F. Doreleijers, Sybren S. Wijmenga, and Ming-Daw Tsai, 2014, Structural conversion of intramolecular and intermolecular G-quadruplexes of bcl2mid: The effect of potassium concentration and ion exchange, J. Am. Chem. Soc., 136, 4927-4937.

(AUC) Kai-En Chen, Shu-Yu Lin, Mei-Ju Wu, Meng-Ru Ho, Abirami Santhanam, Chia-Cheng Chou, Tzu-Ching Meng, and Andrew H. J. Wang, 2014, Reciprocal allosteric regulation of p38γ and PTPN3 involves a PDZ domain–modulated complex formation, Science Signaling, 7(347): ra98.

(AUC) Min Zheng, Ya-Ling Chiang, Hsiao-Lin Lee, Lih-Ren Kong, Shang-Te Danny Hsu, Ing-Shouh Hwang, Lawrence I. Rothfield, and Yu-Ling Shih, 2014, Self-Assembly of MinE on the Membrane Underlies Formation of the MinE-Ring to Sustain Function of the E. coli Min System, J. Biol. Chem., 289, 21252-21266.

(AUC) Tao-Hsin Chang, Shu-Jung Chang, Fu-Lien Hsieh, Tzu-Ping Ko, Cheng-Tse Lin, Meng-Ru Ho, Iren Wang, Shang-Te Danny Hsu, Rey-Ting Guo, Wen Chang, and Andrew H. J. Wang, 2013, Crystal Structure of Vaccinia Viral A27 Protein Reveals a Novel Structure Critical for Its Function and Complex Formation with A26 Protein, PLoS ONE, 9(8): e1003563.

(iTC200) Hsin-Hui Wu, Pei-Yu Wu, Kai-Fa Huang, Yu-Ya Kao, and Ming-Daw Tsai, 2012, Structural Delineation of MDC1-FHA Domain Binding with CHK2-pThr68, Biochemistry, 51, 575-577.

(Biacore T200) Kai-Chuan Chen, Shih-Yen Wu, Yu-Lin Leu, Zeljko M. Prijovich, Bing-Mae Chen, Hsin-Ell Wang, Tian-Lu Cheng, and Steve R. Roffler, 2011, A humanized immunoenzyme with enhanced activity for glucuronide prodrug activation in the tumor microenvironment, Bioconjugate Chem., 22, 938-948.

(Biacore T100) I-Chieh Tseng, Chwan-Yang Hong, Su-May Yu and Tuan-Hua David Ho, 2013, Abscisic acid- and stress- induced highly proline-rich glycoproteins regulate root growth in rice, Plant Physiology, 163, 118-134.

(BCF Staff) Jiahn-Haur Liao, Cheng-Han Tsai, Sanjay G. Patel, Jhih-Tian Yang, I-Fan Tu, Matteo Lo Cicero, Magdalena Lipka-Lloyd, Wan-Ling Wu, Wen-Jie Shen, Meng-Ru Ho, Chi-Chi Chou, Garima R. Sharma, Hiroki Okanishi, Louis Y. P. Luk, Yu-Hsuan Tsai and Shih-Hsiung Wu, 2017, Acetylome of Acinetobacter baumannii SK17 Reveals a Highly-Conserved Modification of Histone-Like Protein HU, Front. Mol. Biosci., 27 November 2017. https://doi.org/10.3389/fmolb.2017.00077

(BCF Staff) Thomas H. Scheuermann, Shae B. Padrick, Kevin H. Gardner, Chad A. Brautigam 2016, On the acquisition and analysis of microscale thermophoresis data, Analytical Biochemistry, 496, 79-93.

(BCF Staff) Yeh-Hsing Lao, Chun-Wei Chi, Sarah M. Friedrich, Konan Peck, Tza-Huei Wang, Kam W. Leong, and Lin-Chi Chen, 2016, Signal-on Protein Detection via Dye Translocation between Aptamer and Quantum Dot, ACS Appl. Mater. Interfaces, 8, 12048−12055.

(BCF Staff) Shu-Yu Huang, Chi-Fon Chang, Pei-Ju Fang, Mandar T. Naik, Peter Gu¨ntert, Hsiu-Ming Shih and Tai-Huang Huang, 2015, The RING domain of human promyelocytic leukemia protein(PML), J Biomol NMR, 61, 173–180.

(BCF Staff) Camy C.-H. Kung, Mandar T. Naik, Szu-Huan Wang, Hsiu-Ming Shih, Che-Chang Chan, Li-Ying Lin, Chia-Lin Chen, Che Ma, Chi-Fon Chang and Tai-Huang Huang, 2014, Structural analysis of poly-SUMO chain recognition by the RNF4-SIMs domain, Biochem. J., 462, 53-65.

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